Evidence map›Paper›PMID 34686685›Full record

ArticleNature communications2021

Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy.

Luyan Wu, Yusuke Ishigaki, Wenhui Zeng, Takashi Harimoto, Baoli Yin, Yinghan Chen, Shiyi Liao, Yongchun Liu, Yidan Sun, Xiaobo Zhang and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  10. An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes.European journal of nuclear medicine and molecular imaging · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Cathepsin K-Activated Probe for Fluoro-Photoacoustic Imaging of Early Osteolytic Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  16. Review
  17. Review
  18. Review
  19. A FRET-Based Ratiometric HResearch (Washington, D.C.) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luyan Wu *State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Yusuke Ishigaki *Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, North-ward, Sapporo, 060-0810, Japan.ORCID 0000-0001-7961-3595
Wenhui Zeng *State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Takashi HarimotoDepartment of Chemistry, Faculty of Science, Hokkaido University, N10 W8, North-ward, Sapporo, 060-0810, Japan.
Baoli YinState Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Yinghan ChenJiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Shiyi LiaoState Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Yongchun LiuState Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
Yidan SunState Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Xiaobo ZhangState Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Ying LiuState Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.ORCID 0000-0001-5718-7804
Yong LiangJiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.ORCID 0000-0001-5026-6710
Pengfei SunState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.
Takanori SuzukiDepartment of Chemistry, Faculty of Science, Hokkaido University, N10 W8, North-ward, Sapporo, 060-0810, Japan. tak@sci.hokudai.ac.jp.ORCID 0000-0002-1230-2044
Guosheng SongState Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. songgs@hnu.edu.cn.ORCID 0000-0001-5628-6245
Quli FanState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China. iamqlfan@njupt.edu.cn.ORCID 0000-0002-9387-0165
Deju YeState Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. dejuye@nju.edu.cn.ORCID 0000-0002-9887-0914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL

Indexed as

AnimalsCell Line, TumorFerroptosisFluorescenceHydroxyl RadicalMiceMolecular ImagingMolecular ProbesNeoplasmsOptical ImagingPhotoacoustic TechniquesSpectroscopy, Near-InfraredHydroxyl RadicalMolecular Probes

Identifiers

PMID34686685
PMCPMC8536768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.