ArticleProceedings of the National Academy of Sciences of the United States of America2021
TLR or NOD receptor signaling skews monocyte fate decision via distinct mechanisms driven by mTOR and miR-155.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Aryl hydrocarbon receptor restrains tonic cytokine responses by inhibiting microbiota sensing in monocytes.The Journal of clinical investigation · 2025Article
- Monocyte-Derived Dendritic Cells: An Updated View on an Old Concept.Immunological reviews · 2025Review
- TNF gives plasmacytoid dendritic cells a new life.Nature immunology · 2025Article
- Inflammatory mechanisms and therapeutic advances in chronic endometritis.Frontiers in immunology · 2025Review
- Fth1-mScarlet Reports Monocyte State during Lipopolysaccharide-induced Lung Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- The Proteomic Landscape of Monocytes in Response to Colorectal Cancer Cells.Journal of proteome research · 2024Article
- Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics.Acta pharmacologica Sinica · 2023Review
- Age-dependent transcriptomic profiles of leukocytes in pediatric population.Clinical immunology (Orlando, Fla.) · 2023Article
- Monocyte regulation by gut microbial signals.Trends in microbiology · 2023Review
- Monocytes differentiate along two alternative pathways during sterile inflammation.EMBO reports · 2023Article
- Phenotypic and functional heterogeneity of monocytes in health and cancer in the era of high dimensional technologies.Blood reviews · 2023Review
- Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells.Frontiers in immunology · 2023Article
- Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner.Frontiers in immunology · 2023Article
- NOD2 in monocytes negatively regulates macrophage development through TNFalpha.Frontiers in immunology · 2023Article
- Ecological insights into hematopoiesis regulation: unraveling the influence of gut microbiota.Gut microbesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocytes are rapidly recruited to inflamed tissues where they differentiate into monocyte-derived macrophages (mo-mac) or dendritic cells (mo-DC). At infection sites, monocytes encounter a broad range of microbial motifs. How pathogen recognition impacts monocyte fate decision is unclear. Here, we show, using an in vitro model allowing the simultaneous differentiation of human mo-mac and mo-DC, that viruses promote mo-mac while Mycobacteria favor mo-DC differentiation. Mechanistically, we found that pathogen sensing through toll-like receptor (TLR) ligands increases mo-mac differentiation via mTORC1. By contrast, nucleotide-binding oligomerization domain (NOD) ligands favor mo-DC through the induction of TNF-α secretion and miR-155 expression. We confirmed these results in vivo, in mouse skin and by analyzing transcriptomic data from human individuals. Overall, our findings allow a better understanding of the molecular control of monocyte differentiation and of monocyte plasticity upon pathogen sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.