ArticleProceedings of the National Academy of Sciences of the United States of America2021
Tungsten enzymes play a role in detoxifying food and antimicrobial aldehydes in the human gut microbiome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The human gut microbeApplied and environmental microbiology · 2026Article
- Classification of tungsten-containing oxidoreductases provides insights into their biochemical and physiological diversity.Frontiers in microbiology · 2026Article
- Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes.BMC microbiology · 2025Article
- Light up the mitochondria: Smart tungstate-oligosaccharide nanoplatform orchestrates mitochondrial transfer from M2 macrophages to restore endothelial function for adaptive diabetic wound regeneration.Materials today. Bio · 2025Article
- An electron-bifurcating "plug" to a protein nanowire in tungsten-dependent aldehyde detoxification.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Obligately Tungsten-Dependent Enzymes─Catalytic Mechanisms, Models and Applications.Biochemistry · 2025Review
- Article
- Colorimetric Determination of Tungsten and Molybdenum in Biological Samples.Bio-protocol · 2025Article
- Bond Valence Sum Parameters for Analyzing Pyranopterin Tungsten Enzyme Structures.Molecules (Basel, Switzerland) · 2025Article
- Supramolecular Entrapping and Extraction of Selenate, Molybdate and Tungstate Ions from Water by Nanojars.Inorganic chemistry · 2025Article
- Tungsten is utilized for lactate consumption and SCFA production by a dominant human gut microbeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fitness factors impacting survival of a subsurface bacterium in contaminated groundwater.The ISME journal · 2024Article
- Advancing Our Understanding of Pyranopterin-Dithiolene Contributions to Moco Enzyme Catalysis.Molecules (Basel, Switzerland) · 2023Review
- A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire.Science advances · 2023Article
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Tungsten toxicity and carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- An unprecedented function for a tungsten-containing oxidoreductase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
- The quintessence of metallomics: a harbinger of a different life science based on the periodic table of the bioelements.Metallomics : integrated biometal science · 2022Article
- Tungsten Enzyme Using Hydrogen as an Electron Donor to Reduce Carboxylic Acids and NADACS catalysis · 2022Article
- Obligately aerobic human gut microbe expresses an oxygen resistant tungsten-containing oxidoreductase for detoxifying gut aldehydes.Frontiers in microbiology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Tungsten (W) is a metal that is generally thought to be seldom used in biology. We show here that a W-containing oxidoreductase (WOR) family is diverse and widespread in the microbial world. Surprisingly, WORs, along with the tungstate-specific transporter Tup, are abundant in the human gut microbiome, which contains 24 phylogenetically distinct WOR types. Two model gut microbes containing six types of WOR and Tup were shown to assimilate W. Two of the WORs were natively purified and found to contain W. The enzymes catalyzed the conversion of toxic aldehydes to the corresponding acid, with one WOR carrying out an electron bifurcation reaction coupling aldehyde oxidation to the simultaneous reduction of NAD
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