Evidence map›Paper›PMID 34686592›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Possible selection bias limits the interpretation of single-cell transcriptomics data of steroid-resistant asthma exacerbation.

Joytri Dutta, Rakhshinda Rehman, Shamsudheen K Vellarikkal, Laura E Fredenburgh, Ulaganathan Mabalirajan

Abstract readLetterComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reply to Dutta et al.: Understanding scRNA-seq data in the context of the tissue microenvironment requires clinical relevance.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Joytri DuttaMolecular Pathobiology of Respiratory Diseases, Cell Biology and Physiology Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal 700032, India.ORCID 0000-0002-9789-0980
Rakhshinda RehmanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0002-1755-3416
Shamsudheen K VellarikkalMedical and Population Genetics Program, Broad Institute of MIT and Harvard University, Cambridge, MA 02142.ORCID 0000-0002-6384-2948
Laura E FredenburghDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0002-7447-6453
Ulaganathan MabalirajanMolecular Pathobiology of Respiratory Diseases, Cell Biology and Physiology Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal 700032, India; mabsome@yahoo.co.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaTranscriptomeHumansSelection BiasSteroidsSteroids

Identifiers

PMID34686592
PMCPMC8639324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.