ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 89 citations in OpenAlex.
- Including two-dimensional pressure-focusing in transmission-line cochlear models.JASA express letters · 2026Article
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- Cochlear synaptic vulnerability scales with pathological noise intensity in a noise-induced hearing loss model.Genes & genomics · 2026Article
- An alternative pathway for delivery of power by outer hair cells to cochlear traveling waves.Hearing research · 2026Article
- Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- Coupled oscillator mechanism extends the amplifying effect of outer hair cells to high frequencies.Scientific reports · 2025Article
- Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Study of organ of Corti motion in the guinea pig base including differential analysis of internal motion.Hearing research · 2025Article
- The impulse response of the organ of Corti at the apex of the intact cochlea.Scientific reports · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.Research square · 2025Article
- Evaluation of thin-slice finite-element models for 3D cochlear organ of Corti mechanics.Hearing research · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.bioRxiv : the preprint server for biology · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- How Exceptional Is the Ear?Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Imaging theJournal of biomedical optics · 2025Article
- The Reduced Cortilymph Flow Path in the Short-Wave Region Allows Outer Hair Cells to Produce Focused Traveling-Wave Amplification.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Mammalian hearing depends on an amplification process involving prestin, a voltage-sensitive motor protein that enables cochlear outer hair cells (OHCs) to change length and generate force. However, it has been questioned whether this prestin-based somatic electromotility can operate fast enough in vivo to amplify cochlear vibrations at the high frequencies that mammals hear. In this study, we measured sound-evoked vibrations from within the living mouse cochlea and found that the top and bottom of the OHCs move in opposite directions at frequencies exceeding 20 kHz, consistent with fast somatic length changes. These motions are physiologically vulnerable, depend on prestin, and dominate the cochlea's vibratory response to high-frequency sound. This dominance was observed despite mechanisms that clearly low-pass filter the in vivo electromotile response. Low-pass filtering therefore does not critically limit the OHC's ability to move the organ of Corti on a cycle-by-cycle basis. Our data argue that electromotility serves as the primary high-frequency amplifying mechanism within the mammalian cochlea.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.