Evidence map›Paper›PMID 34686582›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

IL-36α Enhances Host Defense against

Rao Me, Nan Gao, Yangyang Zhang, Patrick S Y Lee, Jie Wang, Tingting Liu, Theodore J Standiford, Qing-Sheng Mi, Fu-Shin X Yu

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Non-immune and immune functions of interleukin-36γ suppress epithelial repair at the ocular surface.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rao MeDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI.
Nan GaoDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI.
Yangyang ZhangDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI.ORCID 0000-0003-3276-5211
Patrick S Y LeeDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI.ORCID 0000-0002-7203-9831
Jie WangCenter for Cutaneous Biology and Immunology, Department of Dermatology and Immunology Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI; and.ORCID 0000-0001-9732-1975
Tingting LiuCenter for Cutaneous Biology and Immunology, Department of Dermatology and Immunology Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI; and.
Theodore J StandifordDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI.
Qing-Sheng MiCenter for Cutaneous Biology and Immunology, Department of Dermatology and Immunology Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI; and.
Fu-Shin X YuDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI; fyu@wayne.edu.ORCID 0000-0002-8517-2738
Wayne State University · USHenry Ford Health System · USUniversity of Michigan · US

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
MOLECULAR REGULATION OF CORNEAL WOUND HEALINGR01EY010869 · NEI · WAYNE STATE UNIVERSITY · PI YU, FU-SHIN X · 1995 to 2023
$7.7M
Mechanisms of flagellin-induced protection against microbial keratitisR01EY017960 · NEI · WAYNE STATE UNIVERSITY · PI YU, FU-SHIN X · 2008 to 2020
$4.8M
Role of Programmed Cell Death Pathways in Bacterial KeratitisR01EY035785 · NEI · WAYNE STATE UNIVERSITY · PI Fu-Shin X Yu · 2024 to 2026
$1.3M
Class 3 Semaphorins and Impaired Sensory Nerve Regeneration in Diabetic CorneasF30EY025923 · NEI · WAYNE STATE UNIVERSITY · PI LEE, PATRICK SHEAN-YOUNG · 2017 to 2020
$183k
NEI NIH HHS F30 EY025923NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY010869NEI NIH HHS R01 EY017960NEI NIH HHS R01 EY035785
6 · The paper itself

Abstract

The IL-36 cytokines are known to play various roles in mediating the immune response to infection in a tissue- and pathogen-dependent manner. The present study seeks to investigate the role of IL-36R signaling in C57BL/6 mouse corneas in response to

Indexed as

AnimalsCorneaInterleukin-1MiceMice, Inbred C57BLMice, KnockoutPseudomonas aeruginosaPseudomonas InfectionsInterleukin-1interleukin 1F6, mouse

Identifiers

PMID34686582
PMCPMC8612993
OpenAlexW3205453216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.