Evidence map›Paper›PMID 34686396›Full record

ArticleJournal of pediatric nursing

Lower serum selenium concentration associated with anxiety in children.

Jill Portnoy, Jessica Wang, Fenfen Wang, Phoebe Um, Sharon Y Irving, Laura Hackl, Jianghong Liu

Open access · greenAbstract read
In one paragraph

Article in Journal of pediatric nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jill PortnoyUniversity of Massachusetts Lowell, Lowell, MA, USA.
Jessica WangSchool of Nursing, University of Pennsylvania, Philadelphia PA, USA.
Fenfen WangSchool of Nursing, University of Pennsylvania, Philadelphia PA, USA.
Phoebe UmThe Ohio State University College of Medicine, Columbus, OH, USA.
Sharon Y IrvingSchool of Nursing, University of Pennsylvania, Philadelphia PA, USA.
Laura HacklJohn Snow Inc., Arlington, VA, USA.
Jianghong LiuSchool of Nursing, University of Pennsylvania, Philadelphia PA, USA. Electronic address: jhliu@nursing.upenn.edu.
University of Pennsylvania · USJohn Snow (United States) · USThe Ohio State University · USUniversity of Massachusetts Lowell · US

Funding

Omega-3 Supplementation and Adolescent BehaviorR01HD087485 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG, RAINE, ADRIAN · 2017 to 2021
$2.5M
Lead exposure, externalizing behavior, and neurobiological mediating factorsR01ES018858 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2010 to 2014
$1.7M
Mechanisms that mediate the link between lead exposure and child behavior problemK02ES019878 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2011 to 2015
$656k
Environmental Toxicity, Malnutrition, and Children's Externalizing BehaviorK01ES015877 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, JIANGHONG · 2007 to 2010
$605k
NICHD NIH HHS R01 HD087485NIEHS NIH HHS K01 ES015877NIEHS NIH HHS K02 ES019878NIEHS NIH HHS R01 ES018858
6 · The paper itself

Abstract

purposeFew studies have examined the role of selenium in anxiety. This study aimed to evaluate the association between serum selenium concentrations and anxiety disorders and symptoms in children. DESIGN AND

methodsThis study utilized data from 831 children participating in the China Jintan Child Cohort Study (mean age = 12.67 years; 46.1% female). Serum selenium samples were collected and anxiety was assessed using the Chinese version of the Screen for Child Anxiety Related Disorders. Six types of anxiety scores were calculated, including total anxiety, panic/somatic, generalized anxiety, separation anxiety, social anxiety, and school phobia.

resultsControlling for covariates, children with lower serum selenium concentrations were more likely to meet clinical cutoffs for total anxiety (OR = 0.992, p < 0.01), panic/somatic disorder (OR = 0.993, p < 0.05), generalized anxiety disorder (OR = 0.990, p < 0.05), social anxiety disorder (OR = 0.991, p < 0.01), and school phobia (OR = 0.989, p < 0.01), but not separation anxiety (OR = 1.000, p > 0.05). Controlling for covariates, lower serum selenium concentrations were also associated with higher continuous total anxiety, generalized anxiety, and school phobia scores (p < 0.05).

conclusionsLower serum selenium concentrations were associated with higher anxiety. To our knowledge, this was the first study to examine the relationship between serum selenium and anxiety disorders in a sample of children. Results indicate an association between children's micronutrient levels and anxiety disorders. PRACTICE IMPLICATIONS: Improving child nutrition may be a promising strategy to help reduce childhood anxiety.

Indexed as

Panic DisorderSeleniumAnxietyAnxiety DisordersChildCohort StudiesFemaleHumansMaleSeleniumAnxietyChild mental healthMicronutrientsNutritionSerum selenium

Identifiers

PMID34686396
PMCPMC10002467
OpenAlexW3207301186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.