ArticleCell reports2021
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 55 citations in OpenAlex.
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- Slit2/Robo1 signaling constrains image stabilization responses to preserve ethologically favorable directional asymmetry.Current biology : CB · 2025Article
- Comparative Single-Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices.Developmental neuroscience · 2025Article
- Finding spatially variable ligand-receptor interactions with functional support from downstream genes.Nature communications · 2025Article
- Male caregiving experience alters hippocampal neuroplasticity and transcription independent of reproduction in a biparental species.Communications biology · 2025Article
- Rest Induces a Distinct Transcriptional Program in the Nervous System of the ExercisedInternational journal of molecular sciences · 2025Article
- The Slit-Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates.Open biology · 2025Review
- From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons.bioRxiv : the preprint server for biology · 2025Article
- Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons.Nature protocols · 2025Review
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- Multichannel 3D-Printed Bioactive Scaffold Combined with Small Interfering RNA Delivery to Promote Neurological Recovery after Spinal Cord Injury.Research (Washington, D.C.) · 2025Article
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Authors and funding
17 authors at 2 institutions in 2 countries.
Heike BlockusDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Sebi V RolottiDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Miklos SzoboszlayDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Eugénie Peze-HeidsieckDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Tiffany MingDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Anna SchroederVIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Nuno ApostoloVIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Kristel M VennekensVIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Phinikoula S KatsambaZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Fabiana BahnaZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Seetha MannepalliZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Goran AhlsenZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Barry HonigZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Medicine, Columbia University, New York, NY 10032, USA.
Lawrence ShapiroZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Joris de WitVIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Attila LosonczyDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA. Electronic address: al2856@columbia.edu.
Franck PolleuxDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA. Electronic address: fp2304@columbia.edu.
Columbia University · USVIB-KU Leuven Center for Brain & Disease Research · BE
Funding
Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI BUZSAKI, GYORGY, LISMAN, JOHN E · 2017 to 2021
$13.2MFunctions of membrane deforming-proteins during neuronal developmentR01NS067557 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POLLEUX, FRANCK · 2010 to 2020
$4.9MOptimization, application and dissemination of high-speed hybrid multiphoton volumetric imaging technologiesU01NS115530 · NINDS · ROCKEFELLER UNIVERSITY · PI LOSONCZY, ATTILA, VAZIRI, ALIPASHA · 2020 to 2023
$4.7MMicrocircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletionR01MH124047 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A, LOSONCZY, ATTILA · 2020 to 2024
$3.8MExperimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4MThe structural basis of cis and trans protocadherin interactionsR01MH114817 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2017 to 2021
$2.4MSlit-Robo signaling links synapse specificity with functional circuit wiringR21NS109753 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POLLEUX, FRANCK · 2019 to 2019
$446kExploring new roles of Robo2 in synaptic development, plasticity and hippocampal circuit functionK99NS115984 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLOCKUS, HEIKE MANUELA · 2020 to 2020
$120kNIMH NIH HHS R01 MH114817NIMH NIH HHS R01 MH124047NIMH NIH HHS R01 MH124867NINDS NIH HHS K99 NS115984NINDS NIH HHS R01 NS067557NINDS NIH HHS R21 NS109753NINDS NIH HHS U01 NS115530NINDS NIH HHS U19 NS104590
Abstract
Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in hippocampal CA1. In vivo, Robo2 is present and required postsynaptically in CA1 pyramidal neurons (PNs) for the formation of excitatory (E) but not inhibitory (I) synapses, specifically in proximal but not distal dendritic compartments. In vitro approaches show that the synaptogenic activity of Robo2 involves a trans-synaptic interaction with presynaptic Neurexins, as well as binding to its canonical extracellular ligand Slit. In vivo 2-photon Ca
Indexed as
AnimalsCA1 Region, HippocampalCA3 Region, HippocampalCalcium-Binding ProteinsExcitatory Postsynaptic PotentialsHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural Cell Adhesion MoleculesPlace CellsPyramidal CellsCalcium-Binding ProteinsIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsNeural Cell Adhesion Moleculesneurexin 3, mouseneurexin IINrxn1 protein, mouseReceptors, ImmunologicRobo2 protein, mouseRoundabout ProteinsSlit Homolog 2 Proteindendriteshippocampusneurexinsplace cellsSlit-Robosynapse developmentsynaptic adhesion moleculessynaptic specificity
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