Evidence map›Paper›PMID 34686324›Full record

ArticleCell reports2021

Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart.

Anna Kosmach, Barbara Roman, Junhui Sun, Armel Femnou, Fan Zhang, Chengyu Liu, Christian A Combs, Robert S Balaban, Elizabeth Murphy

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Sex differences in mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. MCU-independent CaScientific reports · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anna KosmachCardiovascular Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Barbara RomanCardiovascular Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Junhui SunCardiovascular Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Armel FemnouLabortory of Cardiac Energetics, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Fan ZhangTransgenic Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Chengyu LiuTransgenic Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Christian A CombsLight Microscopy Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Robert S BalabanLabortory of Cardiac Energetics, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: balabanr@nhlbi.nih.gov.
Elizabeth MurphyCardiovascular Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: murphy1@nhlbi.nih.gov.
National Heart Lung and Blood Institute · US

Funding

Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Intramural NIH HHS ZIA HL002066
6 · The paper itself

Abstract

Optical methods for measuring intracellular ions including Ca

Indexed as

Calcium SignalingEnergy MetabolismMyocardial ContractionAdrenergic beta-AgonistsAnimalsCalciumCalcium ChannelsFluorescent DyesHEK293 CellsHeterocyclic Compounds, 3-RingHumansIsolated Heart PreparationIsoproterenolMiceMice, Inbred C57BLMice, KnockoutAdrenergic beta-AgonistsCalciumCalcium ChannelsFluorescent DyesHeterocyclic Compounds, 3-RingIsoproterenolMcu protein, mouseMitochondrial Proteinsrhod-2calciumheartisoproterenolmitochondriaspectroscopy

Identifiers

PMID34686324
PMCPMC10461605
OpenAlexW3205663368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.