Evidence map›Paper›PMID 34686301›Full record

SynthesisAmerican journal of preventive medicine2021

Long-Acting Reversible Contraception, Condom Use, and Sexually Transmitted Infections: A Systematic Review and Meta-analysis.

Riley J Steiner, Sanjana Pampati, Katherine M Kortsmit, Nicole Liddon, Andrea Swartzendruber, Karen Pazol

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in American journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Perceptions and Acceptability of Doxycycline-Based STI Prophylaxis: Insights from Consumers and Healthcare Providers in Queensland.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
    Article
  8. Contextualized Experiences and Predictors of Condom Use in a Flemish Population: A Mixed Methods Study.International journal of environmental research and public health · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Associations Between Recent Contraceptive Use and First Sex Behaviors of Scottish Adolescents: A Brief Report.International journal of sexual health : official journal of the World Association for Sexual Health · 2024
    Article
  13. Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. A non-latex condom has no influence on male physiological sexual arousal.International journal of clinical and health psychology : IJCHP
    Article
  18. Are LARC Users Less Likely to Use Condoms? An Analysis of U.S. Women Initiating LARC in 2008-2018.Women's health issues : official publication of the Jacobs Institute of Women's Health
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Riley J SteinerDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address: rsteiner@cdc.gov.
Sanjana PampatiOak Ridge Institute for Science and Education, Atlanta, Georgia.
Katherine M KortsmitDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nicole LiddonDivision of Adolescent and School Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
Andrea SwartzendruberDepartment of Epidemiology & Biostatistics, University of Georgia College of Public Health, Athens, Georgia.
Karen PazolDivision of Human Development and Disability, Centers for Disease Control and Prevention, Atlanta, Georgia.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

introductionGiven mixed findings regarding the relationship between long-acting reversible contraception and condom use, this systematic review and meta-analysis synthesizes studies comparing sexually transmitted infection‒related outcomes between users of long-acting reversible contraception (intrauterine devices, implants) and users of moderately effective contraceptive methods (oral contraceptives, injectables, patches, rings).

methodsMEDLINE, Embase, PsycINFO, Global Health, CINAHL, Cochrane Library, and Scopus were searched for articles published between January 1990 and July 2018. Eligible studies included those that (1) were published in the English language, (2) were published in a peer-reviewed journal, (3) reported empirical, quantitative analyses, and (4) compared at least 1 outcome of interest (condom use, sexual behaviors other than condom use, sexually transmitted infection‒related service receipt, or sexually transmitted infections/HIV) between users of long-acting reversible contraception and users of moderately effective methods. In 2020, pooled ORs were calculated for condom use, chlamydia/gonorrhea infection, and trichomoniasis infection; findings for other outcomes were synthesized qualitatively. The protocol is registered on the International Prospective Register of Systematic Reviews (CRD42018109489).

resultsA total of 33 studies were included. Long-acting reversible contraception users had decreased odds of using condoms compared with oral contraceptive users (OR=0.43, 95% CI=0.30, 0.63) and injectable, patch, or ring users (OR=0.58, 95% CI=0.48, 0.71); this association remained when limited to adolescents and young adults only. Findings related to multiple sex partners were mixed, and only 2 studies examined sexually transmitted infection testing, reporting mainly null findings. Pooled estimates for chlamydia and/or gonorrhea were null, but long-acting reversible contraception users had increased odds of trichomoniasis infection compared with oral contraceptive users (OR=2.01, 95% CI=1.11, 3.62). DISCUSSION: Promoting condom use specifically for sexually transmitted infection prevention may be particularly important among long-acting reversible contraception users at risk for sexually transmitted infections, including adolescents and young adults.

Indexed as

Long-Acting Reversible ContraceptionSexually Transmitted DiseasesAdolescentCondomsContraceptionHumansSafe SexYoung Adult

Identifiers

PMID34686301
PMCPMC9125421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.