Evidence map›Paper›PMID 34686231›Full record

Observational studyThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2021

Pharmacokinetics of high-dose isoniazid in children affected by multidrug-resistant TB.

J L Winckler, H S Schaaf, H R Draper, H McIlleron, J Norman, L E van der Laan, L Wiesner, P R Donald, A C Hesseling, A J Garcia-Prats

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Observational
  3. Observational
  4. Is a high dose sufficient to achieve high isoniazid exposure in children affected by multidrug-resistant TB?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

J L WincklerDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
H S SchaafDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
H R DraperDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
H McIlleronDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
J NormanDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
L E van der LaanDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
L WiesnerDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
P R DonaldDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
A C HesselingDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
A J Garcia-PratsDesmond Tutu TB Centre, Department of Paediatrics, Stellenbosch University, Cape Town, South Africa.
Desmond Tutu HIV Foundation · ZAStellenbosch University · ZAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

IsoniazidTuberculosis, Multidrug-ResistantAdultAntitubercular AgentsChildChild, PreschoolHumansAntitubercular AgentsIsoniazid

Identifiers

PMID34686231
OpenAlexW3206496640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.