Evidence map›Paper›PMID 34686227›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2021

Is a high dose sufficient to achieve high isoniazid exposure in children affected by multidrug-resistant TB?

J-W C Alffenaar, B J Marais, T A Thomas

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

J-W C AlffenaarFaculty of Medicine and Health, School of Pharmacy, University of Sydney, Sydney, NSW, Australia, Westmead Hospital, Sydney, NSW, Australia, Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW.
B J MaraisMarie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Children´s Hospital Westmead, Sydney, NSW, Australia.
T A ThomasDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
Children's Hospital at Westmead · AUThe University of Sydney · AUUniversity of Virginia · US

Funding

Effects of TB and TB treatment on the pediatric intestinal microbiomeR21AI154259 · NIAID · UNIVERSITY OF VIRGINIA · PI THOMAS, TANIA A · 2020 to 2021
$446k
NIAID NIH HHS R21 AI154259
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

IsoniazidTuberculosis, Multidrug-ResistantAntitubercular AgentsChildHumansAntitubercular AgentsIsoniazid

Identifiers

PMID34686227
PMCPMC9811372
OpenAlexW3206273492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.