SynthesisBMC public health2021
Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort.
Synthesis in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- What are the Experiences of and Interventions for Adult Survivors of Childhood Sexual Abuse in South Asia? A Systematic Review and Narrative Synthesis.Trauma, violence & abuse · 2024Pooled it
- Global Prevalence of Childhood Exposure to Physical Violence within Domestic and Family Relationships in the General Population: A Systematic Review and Proportional Meta-Analysis.Trauma, violence & abuse · 2024Pooled it
- Prevalence of Childhood Adversity and Its Association with Depression, Anxiety, and Psychotic-like Experiences Among Young Indian Adults: A Cross-sectional Study.Indian journal of psychological medicine · 2026Article
- The PAthways to Resilience And Mental health (PARAM) project: protocol for a multi-site developmental cohort in India.BMC psychiatry · 2025Article
- Adverse childhood experiences as predictors of alcohol and tobacco addiction risk among college students in Delhi-NCR, India.Scientific reports · 2025Article
- Providing Buffers, Solving Barriers: Value-Driven Policies and Actions that Protect Clients Today and Increase the Chances of Thriving Tomorrow.Behavior analysis in practice · 2025Article
- Determinants of adverse childhood experiences and substance use among emerging adults in the context of sustainable development goals.PloS one · 2025Article
- Alcohol and psychoactive substance use in a cohort of children followed by child protection in France.Frontiers in psychiatry · 2023Article
- The Associations of Adverse Childhood Experiences (ACEs) With Substance Use in Young Adults: A Systematic Review.Substance abuse : research and treatment · 2023Review
- Adverse childhood experiences and adolescent drug use in the UK: The moderating role of socioeconomic position and ethnicity.SSM - population health · 2022Article
- Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences.Microorganisms · 2022Review
- "At a Young Age, I could not Understand My Problems, But Now I Can… I Have Learned Through My Bad Experiences"-A Community-based Mixed-method Study on Adverse Childhood Experiences among the Youth in Southern India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Adverse Childhood Experiences of Youth in Rural Areas of Delhi: A Cross-sectional Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
28 authors at 10 institutions in 3 countries.
Funding
Abstract
backgroundAdverse childhood experiences (ACEs) increases vulnerability to externalising disorders such as substance misuse. The study aims to determine the prevalence of ACEs and its association with substance misuse.
methodsData from the Consortium on Vulnerability to Externalising Disorders and Addictions (cVEDA) in India was used (n = 9010). ACEs were evaluated using the World Health Organisation (WHO) Adverse Childhood Experiences International Questionnaire whilst substance misuse was assessed using the WHO Alcohol, Smoking and Substance Involvement Screening Test. A random-effects, two-stage individual patient data meta-analysis explained the associations between ACEs and substance misuse with adjustments for confounders such as sex and family structure.
results1 in 2 participants reported child maltreatment ACEs and family level ACEs. Except for sexual abuse, males report more of every individual childhood adversity and are more likely to report misusing substances compared with females (87.3% vs. 12.7%). In adolescents, family level ACEs (adj OR 4.2, 95% CI 1.5-11.7) and collective level ACEs (adj OR 6.6, 95% CI 1.4-31.1) show associations with substance misuse whilst in young adults, child level ACEs such as maltreatment show similar strong associations (adj OR 2.0, 95% CI 1.1-3.5).
conclusionACEs such as abuse and domestic violence are strongly associated with substance misuse, most commonly tobacco, in adolescent and young adult males in India. The results suggest enhancing current ACE resilience programmes and 'trauma-informed' approaches to tackling longer-term impact of ACEs in India.
fundingNewton Bhabha Grant jointly funded by the Medical Research Council, UK (MR/N000390/1) and the Indian Council of Medical Research (ICMR/MRC-UK/3/M/2015-NCD-I).
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