ReviewPlants (Basel, Switzerland)2021
Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development.
Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed.
- Experimental Design-Driven Optimization of Choline-Based Natural Deep Eutectic Solvents for the Extraction of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2026Article
- Bridging Biosynthesis and Bioavailability: Integrated Strategies for Tailoring Soybean Isoflavone Profiles.Comprehensive reviews in food science and food safety · 2026Review
- Computational screening of natural deep eutectic solvents for improving naringenin solubilization and membrane behavior in DMPC liposomes Using COSMO-RS and COSMOmic.Journal of molecular modeling · 2026Article
- Hybrid Application of RSM and ANN to Optimize Natural Deep Eutectic Solvent-Based Distillation ofInternational journal of molecular sciences · 2026Article
- Article
- Precipitation and recovery of soy protein extracted in natural deep eutectic solvents: Emphasizing solvent reusability for sustainable processing.Food chemistry: X · 2026Article
- Development and Characterization of Functional Gummies Enriched with País Grape Extract for Presbyphagia.Gels (Basel, Switzerland) · 2026Article
- Enhancing Antioxidant and Storage Stability of Upcycled Fruit Bars Through NADES-Based Lavender Extract Addition.Molecules (Basel, Switzerland) · 2026Article
- Valorization of Garlic (Molecules (Basel, Switzerland) · 2026Article
- Ultrasonic-Assisted Natural Deep Eutectic Solvent Extraction of Proanthocyanidins fromMolecules (Basel, Switzerland) · 2026Article
- Sustainable Valorization of Peanut Byproducts: An Optimized Green Strategy for High-Yield Resveratrol Extraction.ACS omega · 2026Article
- Ultrasound-Assisted NADES-Based Extraction of Spirulina Bioactives: Bioaccessibility and Intestinal Permeability Assessment Using an In Vitro Digestion/Caco-2 Cell Model and Food Application.Journal of food science · 2026Article
- Effectiveness of Natural Deep Eutectic Solvents (NADES) in Extracting Bioactive Compounds fromACS omega · 2026Article
- Polyphenols in food and food wastes: Extraction, isolation, and health applications.Food chemistry. Molecular sciences · 2026Review
- Phytochemical Content, Antioxidant and Antimicrobial Potential ofMolecules (Basel, Switzerland) · 2026Article
- Ultrasound-Assisted DES Extraction of Black Rice Anthocyanins: Optimization, Characterization, and Bioactivity.Journal of food science · 2026Article
- Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives.Marine drugs · 2026Review
- Chitosan Derivatives: Challenges and Opportunities in the Green and Sustainable Transition Era.Molecules (Basel, Switzerland) · 2026Review
- BCAA Metabolic Dyshomeostasis in Cardiovascular Disease: Pathogenic Mechanisms and Intervention.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Ultrasound-assisted extraction of bioactive birch (Betula sp.) bark triterpenoids using hydrophobic natural deep eutectic solvents.Analytical and bioanalytical chemistry · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.