ReviewPlants (Basel, Switzerland)2021
Enhancement of Phytosterol and Triterpenoid Production in Plant Hairy Root Cultures-Simultaneous Stimulation or Competition?
Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Preliminary Study on the Geochemical Characterization of Viticis Fructus Cuticular Waxes: From Latitudinal Variation to Origin Authentication.International journal of molecular sciences · 2025Article
- Secondary Metabolites in Plants.Plants (Basel, Switzerland) · 2025Article
- A simple and efficient system for evaluating plant genome editing efficiency and its application in optimizing the ISAam1 TnpB nuclease.Frontiers in plant science · 2025Article
- The Untapped Potential of Hairy Root Cultures and Their Multiple Applications.International journal of molecular sciences · 2024Review
- Enhancing Centelloside Production inPlants (Basel, Switzerland) · 2023Article
- Modifications in steroid and triterpenoid metabolism in Calendula officinalis plants and hairy root culture in response to chitosan treatment.BMC plant biology · 2023Article
- Identification of Cumin (Plants (Basel, Switzerland) · 2023Article
- Comparative Transcriptomic Analysis of Genes in the 20-Hydroxyecdysone Biosynthesis in the FernInternational journal of molecular sciences · 2023Article
- Hairy root culture: a potent method for improved secondary metabolite production of Solanaceous plants.Frontiers in plant science · 2023Review
- Heterologous production and characterization of a pyomelanin of Antarctic Pseudomonas sp. ANT_H4: a metabolite protecting against UV and free radicals, interacting with iron from minerals and exhibiting priming properties toward plant hairy roots.Microbial cell factories · 2022Article
- The Influence of Exogenous Jasmonic Acid on the Biosynthesis of Steroids and Triterpenoids inInternational journal of molecular sciences · 2022Article
- Modulation of Steroid and Triterpenoid Metabolism inInternational journal of molecular sciences · 2022Article
- Metabolic Modifications in Terpenoid and Steroid Pathways Triggered by Methyl Jasmonate inPlants (Basel, Switzerland) · 2022Article
- Effect of Ethylene and Abscisic Acid on Steroid and Triterpenoid Synthesis inPlants (Basel, Switzerland) · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant in vitro cultures, including hairy roots, can be applied for controlled production of valuable natural products, such as triterpenoids and sterols. These compounds originate from the common precursor squalene. Sterols and triterpenoids distinctly differ in their functions, and the 2,3-oxidosqualene cyclization step is often regarded as a branch point between primary and secondary (more aptly: general and specialized) metabolism. Considering the crucial role of phytosterols as membrane constituents, it has been postulated that unconstrained biosynthesis of triterpenoids can occur when sterol formation is already satisfied, and these compounds are no longer needed for cell growth and division. This hypothesis seems to follow directly the growth-defense trade-off plant dilemma. In this review, we present some examples illustrating the specific interplay between the two divergent pathways for sterol and triterpenoid biosynthesis appearing in root cultures. These studies were significant for revealing the steps of the biosynthetic pathway, understanding the role of particular enzymes, and discovering the possibility of gene regulation. Currently, hairy roots of many plant species can be considered not only as an efficient tool for production of phytochemicals, but also as suitable experimental models for investigations on regulatory mechanisms of plant metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.