Evidence map›Paper›PMID 34685756›Full record

ArticleCells2021

The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement.

Shimiao Wang, Yuchong Zhang, Weiqi Meng, Yihao Dong, Sujie Zhang, Lesheng Teng, Yang Liu, Lanzhou Li, Di Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shimiao WangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Yuchong ZhangEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Weiqi MengSchool of Life Sciences, Jilin University, Changchun 130012, China.
Yihao DongEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Sujie ZhangEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Lesheng TengSchool of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0000-0003-1623-5384
Yang LiuEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Lanzhou LiSchool of Life Sciences, Jilin University, Changchun 130012, China.
Di WangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jilin University · CNJilin Agricultural University · CN

Funding

Innovation Capacity Building Project of Jilin Provincial Development and Reform Commission 2021C035-6Science and Technology Develop Project in Jilin Province of China 20200708091YY
6 · The paper itself

Abstract

Protein hydrolysate injection (PH) is a sterile solution of hydrolyzed protein and sorbitol that contains 17 amino acids and has a molecular mass of 185.0-622.0 g/mol. This study investigated the effect of PH on hematopoietic function in K562 cells and mice with cyclophosphamide (CTX)-induced hematopoietic dysfunction. In these myelosuppressed mice, PH increased the number of hematopoietic cells in the bone marrow (BM) and regulated the concentration of several factors related to hematopoietic function. PH restored peripheral blood cell concentrations and increased the numbers of hematopoietic stem cells and progenitor cells (HSPCs), B lymphocytes, macrophages, and granulocytes in the BM of CTX-treated mice. Moreover, PH regulated the concentrations of macrophage colony stimulating factor (M-CSF), interleukin (IL)-2, and other hematopoiesis-related cytokines in the serum, spleen, femoral condyle, and sternum. In K562 cells, the PH-induced upregulation of hematopoiesis-related proteins was inhibited by transfection with M-CSF siRNA. Therefore, PH might benefit the BM hematopoietic system via the regulation of M-CSF expression, suggesting a potential role for PH in the treatment of hematopoietic dysfunction caused by cancer therapy.

Indexed as

Amino AcidsAnimalsBone Marrow CellsCyclophosphamideFemurHematopoiesisHumansK562 CellsLeukocytes, MononuclearMacrophage Colony-Stimulating FactorMaleMiceMice, Inbred BALB CMolecular WeightProtein HydrolysatesSternumAmino AcidsCyclophosphamideMacrophage Colony-Stimulating FactorProtein Hydrolysateshematopoietic functionM-CSFprotein hydrolysate injection

Identifiers

PMID34685756
PMCPMC8534652
OpenAlexW3207477171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.