Evidence map›Paper›PMID 34685753›Full record

ArticleCells2021

Chemical Genetic Screen in

Julien Roy Ishibashi, Riya Keshri, Tommy Henry Taslim, Daniel Kennedy Brewer, Tung Ching Chan, Scott Lyons, Anika Marie McManamen, Ashley Chen, Debra Del Castillo, Hannele Ruohola-Baker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025
    Review
  4. Article
  5. A high-throughput method for quantifyingbioRxiv : the preprint server for biology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Julien Roy IshibashiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Riya KeshriDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Tommy Henry TaslimDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Daniel Kennedy BrewerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Tung Ching ChanDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Scott LyonsDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Anika Marie McManamenDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Ashley ChenDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Debra Del CastilloDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Hannele Ruohola-BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5588-4531
University of Washington · US

Funding

Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Controlling Hematopoietic Lineage Commitment from ESC to PlateletsU01HL099993 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TOROK-STORB, BEVERLY J. · 2009 to 2015
$8.3M
MicroRNA Function in Human Embryonic Stem CellsR01GM083867 · NIGMS · UNIVERSITY OF WASHINGTON · PI RUOHOLA-BAKER, HANNELE · 2008 to 2011
$1.5M
Acquisition of Embryonic Stem Cell Metabolic Signature - Minority SupplementR01GM097372 · NIGMS · UNIVERSITY OF WASHINGTON · PI RUOHOLA-BAKER, HANNELE · 2011 to 2014
$1.3M
NHLBI NIH HHS U01 HL099993NHLBI NIH HHS U01 HL099997NIGMS NIH HHS R01 GM083867NIGMS NIH HHS R01 GM084947NIGMS NIH HHS R01 GM097372NIH HHS 1P01GM081619
6 · The paper itself

Abstract

Cancer stem cells, in contrast to their more differentiated daughter cells, can endure genotoxic insults, escape apoptosis, and cause tumor recurrence. Understanding how normal adult stem cells survive and go to quiescence may help identify druggable pathways that cancer stem cells have co-opted. In this study, we utilize a genetically tractable model for stem cell survival in the

Indexed as

Genetic TestingAnimalsApoptosisBreast NeoplasmsDrosophila melanogasterFemaleGerm CellsHumansMaleMCF-7 CellsOrganoidsOvaryPharmaceutical PreparationsRNA InterferenceSmall Molecule LibrariesStem CellsPharmaceutical PreparationsSmall Molecule LibrariesapoptosiscancerDrosophilagermlinequiescenceradiationsmall moleculestem cells

Identifiers

PMID34685753
PMCPMC8534514
OpenAlexW3205045242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.