Evidence map›Paper›PMID 34685747›Full record

ReviewCells2021

Electrical Ventricular Remodeling in Dilated Cardiomyopathy.

Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian André, Norbert Frey, Patrick Lugenbiel, Dierk Thomas

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25-Year Retrospective Analysis From 1999-2024.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Observational
  2. Article
  3. Article
  4. Article
  5. Review
  6. Tumour necrosis factor alpha-induced protein 3-interacting protein 3 overexpression protects against arrhythmogenic remodelling in the heart failure mice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Identification ofDiagnostics (Basel, Switzerland) · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christine MagesDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Heike GamppDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Pascal SyrenDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID 0000-0003-0732-8810
Ann-Kathrin RahmDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Florian AndréDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID 0000-0003-1428-2611
Norbert FreyDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Patrick LugenbielDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Dierk ThomasDepartment of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Heidelberg University · DE

Funding

Deutsche Forschungsgemeinschaft TH 1120/8-1Elisabeth und Rudolf-Hirsch Stiftung für Medizinische Forschung Research GrantErnst und Berta Grimmke-Stiftung Research GrantGerman Cardiac Society Fellowships, Otto-Hess-PromotionsstipendiumGerman Heart Foundation/German Foundation of Heart Research F/08/14, FellowshipGerman Internal Medicine Society Clinician-Scientist-ProgramJoachim Siebeneicher Foundation Research AwardMinistry of Science, Research and the Arts Baden-Wuerttemberg Sonderlinie MedizinUniversity of Heidelberg Faculty of Medicine Postdoctoral Fellowships
6 · The paper itself

Abstract

Ventricular arrhythmias contribute significantly to morbidity and mortality in patients with heart failure (HF). Pathomechanisms underlying arrhythmogenicity in patients with structural heart disease and impaired cardiac function include myocardial fibrosis and the remodeling of ion channels, affecting electrophysiologic properties of ventricular cardiomyocytes. The dysregulation of ion channel expression has been associated with cardiomyopathy and with the development of arrhythmias. However, the underlying molecular signaling pathways are increasingly recognized. This review summarizes clinical and cellular electrophysiologic characteristics observed in dilated cardiomyopathy (DCM) with ionic and structural alterations at the ventricular level. Furthermore, potential translational strategies and therapeutic options are highlighted.

Indexed as

Electrophysiological PhenomenaVentricular RemodelingAnimalsArrhythmias, CardiacCardiomyopathy, DilatedEpigenesis, GeneticHumansTranslational Research, Biomedicaldilated cardiomyopathyion channelremodelingsudden cardiac deathventricular arrhythmia

Identifiers

PMID34685747
PMCPMC8534398
OpenAlexW3207385108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.