Evidence map›Paper›PMID 34685743›Full record

ReviewCells2021

Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions.

Parveen Bazard, Jennifer Pineros, Robert D Frisina, Mark A Bauer, Alejandro A Acosta, Lauren R Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L Mannering, Xiaoxia Zhu and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Parveen BazardDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0001-8729-6112
Jennifer PinerosDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Robert D FrisinaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-7423-6257
Mark A BauerDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Alejandro A AcostaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Lauren R PaganellaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Dominika BorakiewiczDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Mark ThiviergeDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Freyda L ManneringGlobal Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
Xiaoxia ZhuDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Bo DingDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
University of South Florida · US

Funding

Structure and Function Services CoreP01AG009524 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI FRISINA, ROBERT D · 1992 to 2021
$23.2M
NIH HHS P01 AG009524
6 · The paper itself

Abstract

The slow accumulation of inflammatory biomarker levels in the body-also known as inflammaging-has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson's disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)-the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population-and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.

Indexed as

AgingAnimalsCochleaHumansInflammationIon ChannelsMitochondriaNecroptosisIon Channelsage-related hearing lossagingauditory systemcochleainflammaging

Identifiers

PMID34685743
PMCPMC8534887
OpenAlexW3205469678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.