Evidence map›Paper›PMID 34685741›Full record

ArticleCells2021

Comparative Mutational Profiling of Hematopoietic Progenitor Cells and Circulating Endothelial Cells (CECs) in Patients with Primary Myelofibrosis.

Mirko Farina, Simona Bernardi, Nicola Polverelli, Mariella D'Adda, Michele Malagola, Katia Bosio, Federica Re, Camillo Almici, Andrew Dunbar, Ross L Levine and 1 more

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07607392 (JAK2V617F Mutated Endothelium Has a Stem Cell Potential in Primary Myelofibrosis), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07607392 completednot on this mapstarted 2023, after this paper: background citation

JAK2V617F Mutated Endothelium Has a Stem Cell Potential in Primary Myelofibrosis: a New Disease Ontogenesis for Chronic Myeloproliferative Disorders

TypeobservationalSponsorFondazione IRCCS Policlinico San Matteo di PaviaRan2023 to 2026Enrolled30ConditionsPrimary Myelofibrosids
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Myeloproliferative Neoplasms: Contemporary Review and Molecular Landscape.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mirko FarinaUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.ORCID 0000-0002-2980-9028
Simona BernardiUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.ORCID 0000-0002-3494-2624
Nicola PolverelliUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.ORCID 0000-0001-6297-9697
Mariella D'AddaHematology Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Michele MalagolaUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.
Katia BosioUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.
Federica ReUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.ORCID 0000-0003-4219-8695
Camillo AlmiciLaboratory for Stem Cells Manipulation and Cryopreservation, Department of Transfusion Medicine, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0002-9438-2569
Andrew DunbarCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ross L LevineCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Domenico RussoUnit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tissue BankP01CA108671 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ronald Hoffman · 2006 to 2026
$82.0M
American Association for Cancer Research 17-40-11-DUNBNCI NIH HHS P01 CA108671NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A role of endothelial cells (ECs) in Primary Myelofibrosis (PMF) was supposed since

Indexed as

AgedAntigens, CD34Case-Control StudiesEndothelial CellsFemaleHematopoietic Stem CellsHigh-Throughput Nucleotide SequencingHumansMaleMutationPrimary MyelofibrosisAntigens, CD34circulating endothelial cellshematopoiesis-stem and primitive progenitor cellsmolecular geneticsmyelofibrosisvascular biology-endothelial cells

Identifiers

PMID34685741
PMCPMC8534986
OpenAlexW3206848718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.