Evidence map›Paper›PMID 34685710›Full record

ArticleCells2021

Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis.

Yan Yin, Liming Zhu, Qiufang Li, Pengbo Zhou, Liang Ma

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. CRL2BMC biology · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yan YinDepartment of Medicine, Division of Dermatology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Liming ZhuDepartment of Medicine, Division of Dermatology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Qiufang LiDepartment of Medicine, Division of Dermatology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Pengbo ZhouDepartment of Pathology and Laboratory Medicine, The Joan and Stanford I. Weill Medical College of Cornell University, New York, NY 10021, USA.
Liang MaDepartment of Medicine, Division of Dermatology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.ORCID 0000-0001-8013-4903
Washington University in St. Louis · USCornell University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Harnessing the CRL4 ubiquitin ligase for antagonizing colorectal carcinogenesisR01CA213992 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2017 to 2021
$2.7M
G3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate TumorigenesisR01CA221152 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2018 to 2022
$2.4M
GENITALIA OUTGROWTH AND HYPOSPADIASR01DK113642 · NIDDK · WASHINGTON UNIVERSITY · PI MA, LIANG · 2017 to 2021
$1.7M
Retinoic acid signaling in decidualizationR01HD106120 · NICHD · WASHINGTON UNIVERSITY · PI MA, LIANG · 2021 to 2025
$1.7M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA213992NCI NIH HHS R01 CA221152NICHD NIH HHS R01 HD106120NIDDK NIH HHS R01 DK113642
6 · The paper itself

Abstract

Ubiquitination, an essential posttranslational modification, plays fundamental roles during mammalian spermatogenesis. We previously reported the requirement of two Cullin 4 ubiquitin ligase family genes, Cullin 4a (

Indexed as

Cell MovementAnimalsBlood-Testis BarrierCell ProliferationCullin ProteinsFetusGerm CellsHomeostasisMaleMiceSeminiferous TubulesSertoli CellsSexual MaturationCul4a protein, mouseCul4B protein, mouseCullin Proteinsblood-testis barrierCullin4spermatogenesisubiquitination

Identifiers

PMID34685710
PMCPMC8535100
OpenAlexW3205055449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.