Evidence map›Paper›PMID 34685683›Full record

ArticleCells2021

Transcriptomic Biomarkers for Tuberculosis: Validation of

Leonardo S de Araujo, Marcelo Ribeiro-Alves, Matthew F Wipperman, Charles Kyriakos Vorkas, Frank Pessler, Maria Helena Féres Saad

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Biomarker tests of progression from tuberculosis infection to disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Leonardo S de AraujoCellular Microbiology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 20045-360, Brazil.
Marcelo Ribeiro-AlvesNational Institute of Infectology Evandro Chagas, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-8663-3364
Matthew F WippermanImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.ORCID 0000-0003-1436-3366
Charles Kyriakos VorkasImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
Frank PesslerResearch Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, 30519 Hannover, Germany.ORCID 0000-0002-3434-2311
Maria Helena Féres SaadCellular Microbiology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 20045-360, Brazil.
Fundação Oswaldo Cruz · BRMemorial Sloan Kettering Cancer Center · USCenter for Experimental and Clinical Infection Research · DEHelmholtz Centre for Infection Research · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Helmholtz-Gemeinschaft iMedNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

External validation in different cohorts is a key step in the translational development of new biomarkers. We previously described three host mRNA whose expression in peripheral blood is significantly higher (

Indexed as

Disease ProgressionBiomarkersCohort StudiesDiagnosis, DifferentialGene Expression RegulationHumansRNA, MessengerROC CurveTranscription, GeneticTranscriptomeTreatment OutcomeTuberculosisVesicular Transport ProteinsBiomarkersNPC2 protein, humanRNA, MessengerVesicular Transport ProteinsbiomarkersdiagnosismRNAMycobacterium tuberculosisNiemann–Pick disease type C2NPC2RNAtranscriptiontreatmenttuberculosis

Identifiers

PMID34685683
PMCPMC8534371
OpenAlexW3207275369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.