Evidence map›Paper›PMID 34685681›Full record

ArticleCells2021

Enhanced Expression of microRNA-1273g-3p Contributes to Alzheimer's Disease Pathogenesis by Regulating the Expression of Mitochondrial Genes.

So Hee Kim, Kyu Yeong Choi, Yega Park, Catriona McLean, Jiyu Park, Jung Hoon Lee, Kyung-Hwa Lee, Byeong C Kim, Yun Hyun Huh, Kun Ho Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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  15. The Potential Role of miRNA-Regulated Autophagy in Alzheimer's Disease.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

So Hee KimCell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.ORCID 0000-0002-7042-1906
Kyu Yeong ChoiGwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea.
Yega ParkCell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Catriona McLeanDepartment of Pathology, The Alfred Hospital, Melbourne, VIC 3004, Australia.
Jiyu ParkCell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Jung Hoon LeeDepartment of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Kyung-Hwa LeeDepartment of Pathology, Chonnam National University Research Institute of Medical Science, BioMedical Sciences Graduate Program, Chonnam National University Hwasun Hospital and Medical School, Gwangju 58128, Korea.ORCID 0000-0002-3935-0361
Byeong C KimDepartment of Neurology, Chonnam National University Medical School, Gwangju 61469, Korea.ORCID 0000-0001-6827-6730
Yun Hyun HuhSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kun Ho LeeGwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-4144-8162
Woo Keun SongCell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Gwangju Institute of Science and Technology · KRChosun University · KRChonnam National University Hospital · KRDartmouth College · USThe Alfred Hospital · AU

Funding

Ministry of Science ICT and Future Planning 1711120810Ministry of Science ICT and Future Planning 21-BR-03-05National Research Foundation of Korea 2014M3C7A1046041National Research Foundation of Korea 2016R1A5A1007318
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly population, but its underlying cause has not been fully elucidated. Recent studies have shown that microRNAs (miRNAs) play important roles in regulating the expression levels of genes associated with AD development. In this study, we analyzed miRNAs in plasma and cerebrospinal fluid (CSF) from AD patients and cognitively normal (including amyloid positive) individuals. miR-1273g-3p was identified as an AD-associated miRNA and found to be elevated in the CSF of early-stage AD patients. The overexpression of miR-1273g-3p enhanced amyloid beta (Aβ) production by inducing oxidative stress and mitochondrial impairments in AD model cell lines. A biotin-streptavidin pull-down assay demonstrated that miR-1273g-3p primarily interacts with mitochondrial genes, and that their expression is downregulated by miR-1273g-3p. In particular, the miR-1273g-3p-target gene TIMM13 showed reduced expression in brain tissues from human AD patients. These results suggest that miR-1273g-3p expression in an early stage of AD notably contributes to Aβ production and mitochondrial impairments. Thus, miR-1273g-3p might be a biomarker for early diagnosis of AD and a potential therapeutic target to prevent AD progression.

Indexed as

Gene Expression RegulationGenes, MitochondrialAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCell Line, TumorDown-RegulationFemaleHippocampusHumansMaleMicroRNAsMitochondriaAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanMicroRNAsMIRN1273 microRNA, humanMitochondrial Precursor Protein Import Complex ProteinsTIMM13 protein, humanAlzheimer’s diseaseamyloid βcerebrospinal fluidmiR-1273g-3pmitochondriaoxidative stressplasmaTIMM13

Identifiers

PMID34685681
PMCPMC8534383
OpenAlexW3205343947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.