Evidence map›Paper›PMID 34685674›Full record

ArticleCells2021

Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study.

Diana Corallo, Carlo Zanon, Marcella Pantile, Gian Paolo Tonini, Angelica Zin, Samuela Francescato, Bartolomeo Rossi, Eva Trevisson, Claudia Pinato, Ezequiel Monferrer and 6 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Diana CoralloLaboratory of Target Discovery and Biology of Neuroblastoma, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.
Carlo ZanonBioinformatics Core Service, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.
Marcella PantileLaboratory of Target Discovery and Biology of Neuroblastoma, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.
Gian Paolo ToniniLaboratory of Target Discovery and Biology of Neuroblastoma, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.
Angelica ZinAdvanced Diagnostics and Target Discovery in Rare Pediatric Solid Tumors, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.ORCID 0000-0002-7104-273X
Samuela FrancescatoPediatric Hematology, Oncology, and Stem Cell Transplant Center, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.
Bartolomeo RossiPediatric Hematology, Oncology, and Stem Cell Transplant Center, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.
Eva TrevissonClinical Genetics Unit, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.ORCID 0000-0002-5380-6265
Claudia PinatoClinical Genetics Unit, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.
Ezequiel MonferrerPathology Department, Medical School, University of Valencia-INCLIVA, 46010 Valencia, Spain.
Rosa NogueraPathology Department, Medical School, University of Valencia-INCLIVA, 46010 Valencia, Spain.ORCID 0000-0003-4546-7459
Salvador F AliñoPharmacogenetics Unit, Instituto Investigación Sanitaria La Fe and Department Pharmacology, University of Valencia, Avda. Fernando Abril Martorell 106, 46026 Valencia, Spain.
Maria Jose HerreroPharmacogenetics Unit, Instituto Investigación Sanitaria La Fe and Department Pharmacology, University of Valencia, Avda. Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0002-6042-4185
Alessandra BiffiPediatric Hematology, Oncology, and Stem Cell Transplant Center, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.
Elisabetta ViscardiPediatric Hematology, Oncology, and Stem Cell Transplant Center, Department of Woman's and Child's Health, University of Padova, Via Gustiniani 3, 35128 Padova, Italy.
Sanja AveicLaboratory of Target Discovery and Biology of Neuroblastoma, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, C.so Stati Uniti 4, 35127 Padova, Italy.ORCID 0000-0002-3886-4360
University of Padua · ITCittà della Speranza Foundation · ITUniversitat de València · ES

Funding

Fondazione Cassa di Risparmio di Padova e Rovigo 20/11 FCRFundación Científica Asociación Española Contra el Cáncer 2018/150ISCIII and ERDF PT17/0019ISCIII (FIS) and FEDER PI20/01107
6 · The paper itself

Abstract

Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant copy number alterations (CNAs), single nucleotide variants (SNVs), and polymorphisms (SNPs) that were then combined into an integrated analysis. Spontaneously formed 3D tumoroids obtained from the recurrent mass have also been characterized. The results prove the power of combining CNAs, SNVs, and SNPs analyses to assess clonal evolution during the disease progression by evidencing multiple clones at disease onset and dynamic genomic alterations during therapy administration. The proposed molecular and cytogenetic integrated analysis empowers the disease follow-up and the prediction of tumor recurrence.

Indexed as

Comparative Genomic HybridizationExome SequencingChild, PreschoolDisease ProgressionDrug Resistance, NeoplasmFatal OutcomeHumansImmunophenotypingNeuroblastomaPolymorphism, Single Nucleotide3D tumoroidsarray CGHclonal evolutionNeuroblastomapharmacogeneticsrecurrent tumorsingle nucleotide variantswhole exome sequencing

Identifiers

PMID34685674
PMCPMC8534916
OpenAlexW3207337104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.