Evidence map›Paper›PMID 34685619›Full record

ArticleCells2021

CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies.

Carole Luthold, Herman Lambert, Solenn M Guilbert, Marc-Antoine Rodrigue, Margit Fuchs, Alice-Anaïs Varlet, Amélie Fradet-Turcotte, Josée N Lavoie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of BAG3 Protein Interactions in Cardiomyopathies.International journal of molecular sciences · 2024
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carole LutholdCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Herman LambertCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.ORCID 0000-0002-9993-2566
Solenn M GuilbertCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Marc-Antoine RodrigueCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Margit FuchsCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Alice-Anaïs VarletCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Amélie Fradet-TurcotteCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Josée N LavoieCentre de Recherche sur le Cancer, Université Laval, Quebec, QC G1R 3S3, Canada.
Hôtel-Dieu de Québec · CA

Funding

CHU de Québec Foundation 82536CIHR 152948CIHR 7088
6 · The paper itself

Abstract

The cochaperone BCL2-associated athanogene 3 (BAG3), in complex with the heat shock protein HSPB8, facilitates mitotic rounding, spindle orientation, and proper abscission of daughter cells. BAG3 and HSPB8 mitotic functions implicate the sequestosome p62/SQSTM1, suggesting a role for protein quality control. However, the interplay between this chaperone-assisted pathway and the mitotic machinery is not known. Here, we show that BAG3 phosphorylation at the conserved T285 is regulated by CDK1 and activates its function in mitotic cell shape remodeling. BAG3 phosphorylation exhibited a high dynamic at mitotic entry and both a non-phosphorylatable BAG3

Indexed as

Cell ShapeMitosisAdaptor Proteins, Signal TransducingAmino Acid SequenceApoptosis Regulatory ProteinsCDC2 Protein KinaseHeat-Shock ProteinsHEK293 CellsHeLa CellsHumansInclusion BodiesMolecular ChaperonesPhosphorylationPhosphoserineRNA-Binding ProteinsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, humanCDC2 Protein KinaseCDK1 protein, humanHeat-Shock ProteinsHSPB8 protein, humanMolecular ChaperonesP62 protein, humanPhosphoserineRNA-Binding Proteinsactin 7BAG3 1CDK1 4HSPB8 2K63 polyubiquitin chain 8mitotic cell rounding 6p62/SQSTM1 bodies 3protein quality control 9spindle positioning 5

Identifiers

PMID34685619
PMCPMC8534064
OpenAlexW3203835345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.