Evidence map›Paper›PMID 34685611›Full record

ArticleCells2021

'Off-the-Shelf' Immunotherapy: Manufacture of CD8

Nicholas Boyd, Kellie Cartledge, Huimin Cao, Vera Evtimov, Aleta Pupovac, Alan Trounson, Richard Boyd

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. Generation ofHeliyon · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicholas BoydCartherics Pty Ltd., Clayton, VIC 3168, Australia.ORCID 0000-0002-0580-8231
Kellie CartledgeCartherics Pty Ltd., Clayton, VIC 3168, Australia.
Huimin CaoCartherics Pty Ltd., Clayton, VIC 3168, Australia.
Vera EvtimovCartherics Pty Ltd., Clayton, VIC 3168, Australia.
Aleta PupovacCartherics Pty Ltd., Clayton, VIC 3168, Australia.
Alan TrounsonCartherics Pty Ltd., Clayton, VIC 3168, Australia.ORCID 0000-0001-5469-0500
Richard BoydCartherics Pty Ltd., Clayton, VIC 3168, Australia.
CSIRO Manufacturing · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular immunotherapy is revolutionizing cancer treatment. However, autologous transplants are complex, costly, and limited by the number and quality of T cells that can be isolated from and expanded for re-infusion into each patient. This paper demonstrates a stromal support cell-free in vitro method for the differentiation of T cells from umbilical cord blood hematopoietic stem cells (HSCs). For each single HSC cell input, approximately 5 × 10

Indexed as

ImmunotherapyAnimalsCattleCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorCell ProliferationCytotoxicity, ImmunologicFetal BloodHematopoietic Stem CellsHumansPhenotypeCD8+ T cellsdifferentiationHSCoff-the-shelf immunotherapy

Identifiers

PMID34685611
PMCPMC8534391
OpenAlexW3202747057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.