Evidence map›Paper›PMID 34685583›Full record

ReviewCells2021

The Intersection of Purine and Mitochondrial Metabolism in Cancer.

Humberto De Vitto, Danushka B Arachchige, Brian C Richardson, Jarrod B French

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Humberto De VittoDivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
Danushka B ArachchigeDivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
Brian C RichardsonDivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.ORCID 0000-0002-5434-1500
Jarrod B FrenchDivision of Nucleotide Metabolism & Drug Discovery, The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.ORCID 0000-0002-6762-1309
University of Minnesota · US

Funding

Mechanisms that govern assembly and function of higher order protein structures of purine metabolic enzymesR35GM124898 · NIGMS · UNIVERSITY OF MINNESOTA · PI FRENCH, JARROD B · 2017 to 2021
$2.2M
NIGMS NIH HHS R35 GM124898
6 · The paper itself

Abstract

Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.

Indexed as

DNAHumansMitochondriaNeoplasmsPurinesPyrimidinesRNADNAPurinesPyrimidinesRNAamino acidscancersmetabolic reprogrammingmitochondrial metabolismpurines

Identifiers

PMID34685583
PMCPMC8534091
OpenAlexW3204564031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.