Evidence map›Paper›PMID 34685557›Full record

ArticleCells2021

Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy.

Claudia Sacchetto, Zenab Mohseni, Robin M W Colpaert, Libero Vitiello, Marzia De Bortoli, Indira G C Vonhögen, Ke Xiao, Giulia Poloni, Alessandra Lorenzon, Chiara Romualdi and 9 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Plasma Expression andBiomolecules · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Noncoding RNAs and Cardiac Fibrosis.Reviews in cardiovascular medicine · 2023
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Claudia SacchettoDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Zenab MohseniDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Robin M W ColpaertDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Libero VitielloDepartment of Biology, Padova University, 35121 Padova, Italy.
Marzia De BortoliDepartment of Biology, Padova University, 35121 Padova, Italy.ORCID 0000-0002-1348-1304
Indira G C VonhögenDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Ke XiaoInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, D-30625 Hannover, Germany.
Giulia PoloniDepartment of Biology, Padova University, 35121 Padova, Italy.
Alessandra LorenzonDepartment of Biology, Padova University, 35121 Padova, Italy.
Chiara RomualdiDepartment of Biology, Padova University, 35121 Padova, Italy.ORCID 0000-0003-4792-9047
Riccardo BarianiDepartment of Cardiac, Thoracic, and Vascular Sciences, Padova University, 35121 Padova, Italy.ORCID 0000-0002-9120-8709
Elisa MazzottiDepartment of Cardiac, Thoracic, and Vascular Sciences, Padova University, 35121 Padova, Italy.
Luciano DalientoDepartment of Cardiac, Thoracic, and Vascular Sciences, Padova University, 35121 Padova, Italy.
Barbara BauceDepartment of Cardiac, Thoracic, and Vascular Sciences, Padova University, 35121 Padova, Italy.
Domenico CorradoDepartment of Cardiac, Thoracic, and Vascular Sciences, Padova University, 35121 Padova, Italy.
Thomas ThumInstitute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, D-30625 Hannover, Germany.
Alessandra RampazzoDepartment of Biology, Padova University, 35121 Padova, Italy.ORCID 0000-0003-3884-8843
Leon J de WindtDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-7793-2856
Martina CaloreDepartment of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0003-4751-1476
University of Padua · ITMaastricht University · NLMedizinische Hochschule Hannover · DEEurac Research · IT

Funding

ANDROGEN REGULATION OF HUMAN SEBACEOUS GLANDSK08AR002018 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THIBOUTOT, DIANE M. · 1997 to 2001
$225k
European Research Council 311549Hartstichting 2019SB002Hartstichting DCVA2017-2018ARENA-PRIMEMarie Sklodowska-Curie Actions 813716Nederlandse Organisatie voor Wetenschappelijk Onderzoek 918-156-47Università degli Studi di Padova CPDA133979/13
6 · The paper itself

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease characterized by progressive myocardial fibro-fatty replacement, arrhythmias and risk of sudden death. Its diagnosis is challenging and often it is achieved after disease onset or postmortem. In this study, we sought to identify circulating microRNAs (miRNAs) differentially expressed in ARVC patients compared to healthy controls. In the pilot study, we screened the expression of 754 miRNAs from 21 ARVC patients and 20 healthy controls. After filtering the miRNAs considering a log fold-change cut-off of ±1,

Indexed as

AdultArrhythmogenic Right Ventricular DysplasiaBiomarkersCardiomyopathiesCase-Control StudiesFemaleHumansMaleMicroRNAsPilot ProjectsBiomarkersMicroRNAsMIRN185 microRNA, humanarrhythmogenic right ventricular cardiomyopathybiomarkerscirculating microRNAsgeneticsheart failureMicroRNAs

Identifiers

PMID34685557
PMCPMC8533962
OpenAlexW3201847594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.