Evidence map›Paper›PMID 34685549›Full record

ArticleCells2021

Evaluation of an RNAseq-Based Immunogenomic Liquid Biopsy Approach in Early-Stage Prostate Cancer.

Leander Van Neste, Kirk J Wojno, Ricardo Henao, Shrikant Mane, Howard Korman, Jason Hafron, Kenneth Kernen, Rima Tinawi-Aljundi, Mathew Putzi, Amin I Kassis and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05370300 (Subtraction Normalized Aggregated Phagocytic Signal in Peripheral Blood of Breast Cancer Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05370300 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Subtraction Normalized Aggregated Phagocytic Signal in Peripheral Blood of Breast Cancer Patients (SNAPS - Clinical Trial) A NextGen RNASeq Feasibility Study of a Blood-based Model for Early Cancer Detection and Surveillance

TypeobservationalSponsorImmunis.AIRan2025 to 2027Enrolled500ConditionsBreast Cancer, Breast Cancer FemaleArmsBlood test
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Leander Van NesteImmunis.AI, Royal Oak, MI 48067, USA.
Kirk J WojnoImmunis.AI, Royal Oak, MI 48067, USA.
Ricardo HenaoInfinia ML, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-4980-845X
Shrikant ManeYale University Center for Genomic Analysis, New Haven, CT 06511, USA.
Howard KormanComprehensive Urology Center, Royal Oak, MI 48073, USA.
Jason HafronMichigan Institute of Urology, St. Clair Shores, MI 48081, USA.
Kenneth KernenMichigan Institute of Urology, St. Clair Shores, MI 48081, USA.
Rima Tinawi-AljundiMichigan Institute of Urology, St. Clair Shores, MI 48081, USA.
Mathew PutziUrology Austin, Austin, TX 78705, USA.
Amin I KassisImmunis.AI, Royal Oak, MI 48067, USA.
Philip W KantoffMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michigan Institute of Urology · USRoyal Oak Community Coalition · USDuke University · USHarvard University · USMemorial Sloan Kettering Cancer Center · USWayne State University · USYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The primary objective of this study is to detect biomarkers and develop models that enable the identification of clinically significant prostate cancer and to understand the biologic implications of the genes involved. Peripheral blood samples (1018 patients) were split chronologically into independent training (

Indexed as

HumansLiquid BiopsyMaleMiddle AgedNeoplasm StagingProstatic NeoplasmsSequence Analysis, RNAboostingcancerCD14+CD2+cellsgradientimmunephagocytosistranscriptomics

Identifiers

PMID34685549
PMCPMC8533765
OpenAlexW3204174843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.