Evidence map›Paper›PMID 34685506›Full record

ArticleCells2021

Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury.

Yoshitaka Nagashima, Yusuke Nishimura, Fumiharu Ohka, Kaoru Eguchi, Kosuke Aoki, Hiroshi Ito, Tomoya Nishii, Takahiro Oyama, Masahito Hara, Yotaro Kitano and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Yoshitaka NagashimaDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.ORCID 0000-0001-9346-1663
Yusuke NishimuraDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Fumiharu OhkaDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Kaoru EguchiDepartment of Neurosurgery, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan.
Kosuke AokiDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.ORCID 0000-0002-3274-5272
Hiroshi ItoDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Tomoya NishiiDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Takahiro OyamaDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Masahito HaraDepartment of Neurosurgery, Aichi Medical University, Nagakute 480-1195, Japan.
Yotaro KitanoDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.ORCID 0000-0003-1344-2548
Hirano MasakiDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Toshihiko WakabayashiDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Atsushi NatsumeDepartment of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan.
Nagoya University · JPAichi Cancer Center · JPAichi Medical University · JPKawamura Hospital · JPMie University · JPNational Hospital Organization · JP

Funding

Japan Society for the Promotion of Science London 19K09453
6 · The paper itself

Abstract

Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/IV, three cases).

Indexed as

AdolescentAdultFemaleGliomaHistonesHumansMaleMiddle AgedMutationPromoter Regions, GeneticSpinal CordSpinal Cord InjuriesSpinal NeoplasmsTelomeraseYoung AdultHistonesTelomerasediffuse midline gliomageneticgliomaH3F3AH3K27MIDHmutationspinal cord astrocytoma

Identifiers

PMID34685506
PMCPMC8533877
OpenAlexW3204812892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.