Evidence map›Paper›PMID 34685495›Full record

ArticleCells2021

Irradiation Suppresses IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8

Chun-I Wang, Yi-Fang Chang, Zong-Lin Sie, Ai-Sheng Ho, Jung-Shan Chang, Cheng-Liang Peng, Chun-Chia Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Radiotherapy enhances CXCR3Cancer immunology, immunotherapy : CII · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Chun-I WangRadiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou 333, Taiwan.ORCID 0000-0001-8332-0162
Yi-Fang ChangDivision of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
Zong-Lin SieRadiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou 333, Taiwan.ORCID 0000-0002-3063-9927
Ai-Sheng HoDivision of Gastroenterology, Cheng Hsin General Hospital, Taipei 112, Taiwan.
Jung-Shan ChangGraduate Institute of Medical Sciences, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Cheng-Liang PengInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 325, Taiwan.
Chun-Chia ChengRadiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou 333, Taiwan.ORCID 0000-0002-6455-1798
Chang Gung University · TWAtomic Energy Council · TWCheng Hsin General Hospital · TWMackay Memorial Hospital · TWTaipei Medical University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 109-2314-B-182-011Ministry of Science and Technology, Taiwan MOST 110-2314-B-182-003-MY3Ministry of Science and Technology, Taiwan MOST 110-2314-B-182-031
6 · The paper itself

Abstract

Tumor cells express immune checkpoints to exhaust CD8

Indexed as

RadiotherapyB7-H1 AntigenCD8-Positive T-LymphocytesCell ProliferationHumansImmunotherapyInterferon-gammaLung NeoplasmsMyeloid Cell Leukemia Sequence 1 ProteinB7-H1 AntigenCD274 protein, humanInterferon-gammaMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinCD8+ T cellsirradiationMCL1non-small-cell lung cancerPD-L1radiotherapySTAT1STAT3

Identifiers

PMID34685495
PMCPMC8533912
OpenAlexW3201260850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.