Evidence map›Paper›PMID 34685493›Full record

ReviewCells2021

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier.

Ruiyi Zhang, Mengzhou Xue, Voon Wee Yong

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

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  10. LXR agonism for CNS diseases: promises and challenges.Journal of neuroinflammation · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ruiyi ZhangThe Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, Canada.
Mengzhou XueThe Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.
Voon Wee YongThe Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, Canada.ORCID 0000-0002-2600-3563
University of Calgary · CASecond Affiliated Hospital of Zhengzhou University · CN

Funding

CIHR 1049959
6 · The paper itself

Abstract

Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.

Indexed as

AnimalsCentral Nervous SystemCerebral HemorrhageHumansMicrogliaNeuronsRegenerationStrokeangiogenesisbiomaterialdrug therapyintracerebral hemorrhageneurogenesisneuroinflammationrehabilitationremyelinationstem cellstissue regeneration

Identifiers

PMID34685493
PMCPMC8534252
OpenAlexW3200828984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.