Evidence map›Paper›PMID 34685478›Full record

ArticleLife (Basel, Switzerland)2021

The Inhibitory Effect of Noscapine on the In Vitro Cathepsin G-Induced Collagen Expression in Equine Endometrium.

Ana Amaral, Carina Fernandes, Anna Szóstek-Mioduchowska, Karolina Lukasik, Maria Rosa Rebordão, Pedro Pinto-Bravo, Dariusz Jan Skarzynski, Graça Ferreira-Dias

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ana AmaralCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0002-0075-262X
Carina FernandesCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.
Anna Szóstek-MioduchowskaInstitute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.
Karolina LukasikInstitute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.ORCID 0000-0003-2476-8818
Maria Rosa RebordãoCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0002-4389-445X
Pedro Pinto-BravoPolytechnic of Coimbra, Coimbra Agriculture School, Bencanta, 3045-601 Coimbra, Portugal.ORCID 0000-0001-9442-7539
Dariusz Jan SkarzynskiInstitute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.ORCID 0000-0001-9537-3560
Graça Ferreira-DiasCIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Departamento de Morfologia e Função, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.ORCID 0000-0003-0622-6513
University of Lisbon · PTInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences · PLPolytechnic Institute of Coimbra · PT

Funding

Fundação para a Ciência e Tecnologia PTDC/CVT-REP/4202/2014Fundação para a Ciência e Tecnologia SFRH/BD/101058/2014Fundação para a Ciência e Tecnologia UIDB/00276/2020Narodowa Agencja Wymiany Akademickiej PPN/BIL/2018/1/00250/U/0001
6 · The paper itself

Abstract

Cathepsin G (CAT) is a protease released by neutrophils when forming neutrophil extracellular traps that was already associated with inducing type I collagen (COL1) in equine endometrium in vitro. Endometrosis is a fibrotic condition mainly characterized by COL1 deposition in the equine endometrium. The objective was to evaluate if noscapine (an alkaloid for cough treatment with anti-neoplastic and anti-fibrotic properties) would reduce

Indexed as

cathepsin Gcollagenendometrosisequinefibrosisinhibitionnoscapine

Identifiers

PMID34685478
PMCPMC8539599
OpenAlexW3207179508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.