ArticleLife (Basel, Switzerland)2021
The Pupillary Light Reflex as a Biomarker of Concussion.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Human melanopsin (OPN4) gene polymorphisms: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Pupillary Light Reflex and Eye Movement Parameters as Objective Measures of Cognitive Decline in Older Adults: A Secondary Analysis of a Multimodal Public Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Correlation Between Accommodative Facility and Light-Evoked Pupil Responses in Individuals with History of Mild Traumatic Brain Injury.Journal of eye movement research · 2026Article
- Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages.International journal of ophthalmology · 2026Article
- Digital Innovations for Clinical Assessment in Acquired Brain Injury: Scoping Review.Journal of medical Internet research · 2025Article
- Post-concussion clinical findings of oculomotor function in paediatric patients with persisting symptoms compared to healthy controls.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Automatic detection of cognitive events using machine learning and understanding models' interpretations of human cognition.Scientific reports · 2025Article
- Video-based pupillometry using Fourier Mellin image correlation.Scientific reports · 2025Article
- Observational
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Smartphone-based pupillometry in resource-limited settings: an 'eye-catching' prospect.Brain & spine · 2025Article
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- Smartphone-Based Pupillometry Using Machine Learning for the Diagnosis of Sports-Related Concussion.Diagnostics (Basel, Switzerland) · 2024Article
- The Role of Concussion History and Biological Sex on Pupillary Light Reflex Metrics in Adolescent Rugby Players: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2024Article
- Comparison of an AI-based mobile pupillometry system and NPi-200 for pupillary light reflex and correlation with glaucoma-related markers.Frontiers in neurology · 2024Article
- Smartphone Pupillometry and Machine Learning for Detection of Acute Mild Traumatic Brain Injury: Cohort Study.JMIR neurotechnology · 2024Article
- Autonomic nervous system dysfunction in pediatric sport-related concussion: a systematic review.The Journal of the Canadian Chiropractic Association · 2023Article
- Precision Concussion Management: Approaches to Quantifying Head Injury Severity and Recovery.Brain sciences · 2023Review
- Vision as a piece of the head trauma puzzle.Eye (London, England) · 2023Review
- Traumatic brain injury: Mechanisms, manifestations, and visual sequelae.Frontiers in neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The size of our pupils changes continuously in response to variations in ambient light levels, a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its function is modulated by cognitive brain function and any long-term changes in brain function secondary to injury should cause a change in the parameters of the PLR. We performed a retrospective clinical review of the PLR of our patients using the BrightLamp Reflex iPhone app. The PLR variables of latency, maximum pupil diameter (MaxPD), minimum pupil diameter (MinPD), maximum constriction velocity (MCV), and the 75% recovery time (75% PRT) were associated with significant differences between subjects who had suffered a concussion and those that had not. There were also significant differences in PLR metrics over the life span and between genders and those subjects with and without symptoms. The differences in PLR metrics are modulated not only by concussion history but also by gender and whether or not the person has symptoms associated with a head injury. A concussive injury to the brain is associated with changes in the PLR that persist over the life span, representing biomarkers that might be used in clinical diagnosis, treatment, and decision making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.