Evidence map›Paper›PMID 34685474›Full record

ReviewLife (Basel, Switzerland)2021

Hearing Loss and Cognitive Impairment: Epidemiology, Common Pathophysiological Findings, and Treatment Considerations.

Antonella Bisogno, Alfonso Scarpa, Stefano Di Girolamo, Pietro De Luca, Claudia Cassandro, Pasquale Viola, Filippo Ricciardiello, Antonio Greco, Marco De Vincentiis, Massimo Ralli and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. A meta-analytic approach to identification of clinical biomarkers of hearing loss in cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Evaluating the Impact of Cochlear Implantation on Cognitive Outcomes in Older Adults: A 5-Year Follow-Up.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Antonella BisognoDepartment of Otolaryngology, University of Salerno, 84125 Salerno, Italy.ORCID 0000-0003-1158-3582
Alfonso ScarpaDepartment of Otolaryngology, University of Salerno, 84125 Salerno, Italy.
Stefano Di GirolamoDepartment of Otolaryngology, Tor Vergata University, 00133 Roma, Italy.
Pietro De LucaDepartment of Otolaryngology, University of Salerno, 84125 Salerno, Italy.ORCID 0000-0002-6505-1680
Claudia CassandroDepartment of Otolaryngology, University of Turin, 10126 Turin, Italy.
Pasquale ViolaUnit of Audiology, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-2352-1146
Filippo RicciardielloDepartment of Otolaryngology, Cardarelli Hospital, 80131 Napoli, Italy.
Antonio GrecoDepartment of Sense Organs, Sapienza University of Rome, 00161 Rome, Italy.
Marco De VincentiisDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Massimo RalliDepartment of Sense Organs, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8776-0421
Arianna Di StadioOtolaryngology Department, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0001-5510-3814
Sapienza University of Rome · ITUniversity of Salerno · ITFatebenefratelli Hospital · ITMagna Graecia University · ITUniversity of Perugia · ITUniversity of Rome Tor Vergata · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, there has been increasing research interest in the correlation between hearing impairment and cognitive decline, two conditions that have demonstrated a strong association. Hearing loss appears as a risk factor for cognitive impairment, especially among certain populations, notably nursing home residents. Furthermore, hearing loss has been identified as a modifiable age-related condition linked to dementia, and it has been estimated that midlife hearing loss, if eliminated, might decrease the risk of dementia in the general population. Several mechanisms have been suggested to explain the pathologic connections between hearing loss and dementia; however, clear evidence is missing, and the common pathophysiological basis is still unclear. In this review, we discussed current knowledge about the relationship between hearing loss and dementia, and future perspectives in terms of the effects of hearing rehabilitation for early prevention of cognitive decline.

Indexed as

Alzheimer’s diseasecognitive impairmentdementiaepidemiologyhearing aidhearing losspathophysiologyrisk factors

Identifiers

PMID34685474
PMCPMC8538578
OpenAlexW3207030415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.