Evidence map›Paper›PMID 34685397›Full record

ReviewLife (Basel, Switzerland)2021

Post-Mastectomy Pain: An Updated Overview on Risk Factors, Predictors, and Markers.

Marco Calapai, Emanuela Esposito, Luisa Puzzo, Daniele Alfio Vecchio, Rosario Blandino, Giuseppe Bova, Domenico Quattrone, Carmen Mannucci, Ilaria Ammendolia, Cristina Mondello and 3 more

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05713786 completednot on this map

Effects of Physical Exercise and Motor Activity on Post-mastectomy Pain.

TypeobservationalSponsorAzienda Ospedaliera Universitaria Policlinico "G. Martino"Ran2021 to 2022Enrolled126ConditionsChronic Pain
NCT06123559 completednot on this mapstarted 2023, after this paper: background citation

Effects of Physical Exercise and Motor Activity on Depression and Anxiety in Post-Mastectomy Pain Syndrome

TypeobservationalSponsorAzienda Ospedaliera Universitaria Policlinico "G. Martino"Ran2023 to 2023Enrolled160ConditionsChronic Pain
NCT06803563 completednot on this mapstarted 2024, after this paper: background citation

Effects of Physical Exercise and Motor Activity on Sleep Disorders in Post-Mastectomy Pain Syndrome

TypeobservationalSponsorGioacchino CalapaiRan2024 to 2024Enrolled180ConditionsChronic Pain Syndrome
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Marco CalapaiBreast Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Emanuela EspositoGenetics and Pharmacogenetics Unit, Policlinico Universitario "G. Martino", University of Messina, 98125 Messina, Italy.
Luisa PuzzoBreast Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Daniele Alfio VecchioBreast Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Rosario BlandinoBreast Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Giuseppe BovaPain Therapy Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Domenico QuattronePain Therapy Unit, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Carmen MannucciDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy.ORCID 0000-0003-1292-6284
Ilaria AmmendoliaDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Cristina MondelloDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-4489-9631
Sebastiano GangemiSchool and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Gioacchino CalapaiDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy.
Luigi CardiaDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-7286-5674
University of Messina · ITAzienda ospedaliera "Bianchi-Melacrino-Morelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After breast surgery, women frequently develop chronic post-mastectomy pain (PMP). PMP refers to the occurrence of pain in and around the area of the mastectomy lasting beyond three months after surgery. The nature of factors leading to PMP is not well known. When PMP is refractory to analgesic treatment, it negatively impacts the lives of patients, increasing emotional stress and disability. For this reason, optimizing the quality of life of patients treated for this pathology has gained more importance. On the basis of the findings and opinions above, we present an overview of risk factors and predictors to be used as potential biomarkers in the personalized management of individual PMP. For this overview, we discuss scientific articles published in peer-reviewed journals written in the English language describing risk factors, predictors, and potential biomarkers associated with chronic pain after breast surgery. Our overview confirms that the identification of women at risk for PMP is fundamental to setting up the best treatment to prevent this outcome. Clinical practice can be planned through the interpretation of genotyping data, choosing drugs, and tailoring doses for each patient with the aim to provide safer and more effective individual analgesic treatment.

Indexed as

biomarkerschronic painmastectomypost-mastectomy painpost-mastectomy pain syndromepredictorsrisk factors

Identifiers

PMID34685397
PMCPMC8540201
OpenAlexW3204502439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.