ArticleLife (Basel, Switzerland)2021
Thermodynamics of Potential CHO Metabolites in a Reducing Environment.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Strands in a Web: Free Energies of Select Prebiotic Reactions with Sugars, Nitriles and Azoles.Life (Basel, Switzerland) · 2026Article
- The Formose Reaction with SOLife (Basel, Switzerland) · 2026Article
- Sustainable COScientific reports · 2026Article
- Sugars to Acids via Thioesters: A Computational Study.Life (Basel, Switzerland) · 2025Article
- Sulfur Analogs of the Core Formose Cycle: A Free Energy Map.Life (Basel, Switzerland) · 2024Article
- Exploring the Core Formose Cycle: Catalysis and Competition.Life (Basel, Switzerland) · 2024Article
- Preliminary Free Energy Map of Prebiotic Compounds Formed from COLife (Basel, Switzerland) · 2022Article
- Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How did metabolism arise and evolve? What chemical compounds might be suitable to support and sustain a proto-metabolism before the advent of more complex co-factors? We explore these questions by using first-principles quantum chemistry to calculate the free energies of CHO compounds in aqueous solution, allowing us to probe the thermodynamics of core extant cycles and their closely related chemical cousins. By framing our analysis in terms of the simplest feasible cycle and its permutations, we analyze potentially favorable thermodynamic cycles for CO
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