Evidence map›Paper›PMID 34685353›Full record

ArticlePolymers2021

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination.

Zhepeng Liu, Jing Wang, Haini Chen, Guanyu Zhang, Zhuman Lv, Yijun Li, Shoujin Zhao, Wenlin Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Mechanobiology of Myelin Generation/Regeneration in Health and Disease.Results and problems in cell differentiation · 2026
    Review
  2. Orthogonal design-drivenRSC advances · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhepeng LiuSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0003-3115-2210
Jing WangSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Haini ChenSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Guanyu ZhangDepartment of Cell Biology, Second Military Medical University, Shanghai 200433, China.
Zhuman LvDepartment of Cell Biology, Second Military Medical University, Shanghai 200433, China.
Yijun LiSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Shoujin ZhaoSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Wenlin LiDepartment of Cell Biology, Second Military Medical University, Shanghai 200433, China.
University of Shanghai for Science and Technology · CNSecond Military Medical University · CN

Funding

National Natural Science Foundation of China 81571094
6 · The paper itself

Abstract

Myelin sheaths are essential in maintaining the integrity of axons. Development of the platform for in vitro myelination would be especially useful for demyelinating disease modeling and drug screening. In this study, a fiber scaffold with a core-shell structure was prepared in one step by the coaxial electrospinning method. A high-molecular-weight polymer poly-L-lactic acid (PLLA) was used as the core, while the shell was a natural polymer material such as hyaluronic acid (HA), sodium alginate (SA), or chitosan (CS). The morphology, differential scanning calorimetry (DSC), Fourier transform infrared spectra (FTIR), contact angle, viability assay, and in vitro myelination by oligodendrocytes were characterized. The results showed that such fibers are bead-free and continuous, with an average size from 294 ± 53 to 390 ± 54 nm. The DSC and FTIR curves indicated no changes in the phase state of coaxial brackets. Hyaluronic acid/PLLA coaxial fibers had the minimum contact angle (53.1° ± 0.24°). Myelin sheaths were wrapped around a coaxial electrospun scaffold modified with water-soluble materials after a 14-day incubation. All results suggest that such a scaffold prepared by coaxial electrospinning potentially provides a novel platform for oligodendrocyte myelination.

Indexed as

coaxial electrospinningextracellular matrixmyelinationoligodendrocytewater-soluble materials

Identifiers

PMID34685353
PMCPMC8537353
OpenAlexW3207154115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.