Evidence map›Paper›PMID 34685316›Full record

ArticlePolymers2021

The Effect of the PVA/Chitosan/Citric Acid Ratio on the Hydrophilicity of Electrospun Nanofiber Meshes.

Zsuzsanna Czibulya, Attila Csík, Ferenc Tóth, Petra Pál, István Csarnovics, Romána Zelkó, Csaba Hegedűs

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 39 citations in OpenAlex.

  1. Electrospun Poly(vinylpyrrolidone)/Materials (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zsuzsanna CzibulyaBiomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 98. Nagyerdei Blvd, H-4032 Debrecen, Hungary.
Attila CsíkLaboratory of Materials Science, Institute for Nuclear Research (ATOMKI), 18/c Bem Square, H-4026 Debrecen, Hungary.ORCID 0000-0002-8173-9653
Ferenc TóthBiomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 98. Nagyerdei Blvd, H-4032 Debrecen, Hungary.ORCID 0000-0002-1170-6274
Petra PálDepartment of Experimental Physics, Faculty of Science and Technology, University of Debrecen, 18/a Bem Square, H-4002 Debrecen, Hungary.
István CsarnovicsDepartment of Experimental Physics, Faculty of Science and Technology, University of Debrecen, 18/a Bem Square, H-4002 Debrecen, Hungary.ORCID 0000-0002-5528-558X
Romána ZelkóUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, 7-9 Hőgyes Street, H-1092 Budapest, Hungary.ORCID 0000-0002-5419-9137
Csaba HegedűsBiomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 98. Nagyerdei Blvd, H-4032 Debrecen, Hungary.ORCID 0000-0003-4143-2507
University of Debrecen · HUHUN-REN Institute for Nuclear Research · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, scaffolds were prepared via an electrospinning method for application in oral cavities. The hydrophilicity of the fiber mesh is of paramount importance, as it promotes cell spreading; however, the most commonly used polyvinyl alcohol (PVA) and other hydrophilic fiber meshes immediately disintegrate in aqueous media. In contrast, the excessive hydrophobicity of the scaffolds already inhibits cells adhesion on the surface. Therefore, the hydrophilicity of the fiber meshes needed to be optimized. Scaffolds with different polyvinyl alcohol (PVA)/chitosan/citric acid ratios were prepared. The addition of chitosan and the heat initiated cross-linkage of the polymers via citric acid enhanced the scaffolds' hydrophobicity. The optimization of this property could be followed by contact angle measurements, and the increased number of cross-linkages were also supported by IR spectroscopy results. The fibers' physical parameters were monitored via low-vacuum scanning electron microscopy (SEM) and atomic force microscopy (AFM). As biocompatibility is essential for dental applications, Alamar Blue assay was used to prove that meshes do not have any negative effects on dental pulp stem cells. Our results showed that the optimization of the fiber nets was successful, as they will not disintegrate in intraoral cavities during dental applications.

Indexed as

chitosancitric acidelectrospinninghydrophilicitypolyvinyl alcohol

Identifiers

PMID34685316
PMCPMC8540897
OpenAlexW3205352799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.