Evidence map›Paper›PMID 34685018›Full record

ReviewNanomaterials (Basel, Switzerland)2021

The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers.

Lucas F Freitas, Aryel H Ferreira, Velaphi C Thipe, Gustavo H C Varca, Caroline S A Lima, Jorge G S Batista, Fabiane N Riello, Kamila Nogueira, Cassia P C Cruz, Giovanna O A Mendes and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Nanoparticles: An Emerging Hope in Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Heterobivalent Dual-Target Peptide for Integrin-αPharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lucas F FreitasNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.ORCID 0000-0001-7934-9421
Aryel H FerreiraNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Velaphi C ThipeNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Gustavo H C VarcaNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-6545-237X
Caroline S A LimaNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Jorge G S BatistaNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Fabiane N RielloNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-0094-287X
Kamila NogueiraNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Cassia P C CruzNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Giovanna O A MendesNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.ORCID 0000-0003-2348-3810
Adriana S RodriguesNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Thayna S SousaNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Victoria M AlvesNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
Ademar B LugãoNuclear and Energy Research Institute, IPEN-CNEN/SP, Sao Paulo 05508-000, Brazil.
National Nuclear Energy Commission · BRUniversidade Presbiteriana Mackenzie · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico N/AFundação de Amparo à Pesquisa do Estado de São Paulo Process 2018/15598-2; Process 2019/01315-1
6 · The paper itself

Abstract

The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.

Indexed as

breast cancerlung cancernanomaterialsnanotechnologyprostate cancertheranostics

Identifiers

PMID34685018
PMCPMC8539690
OpenAlexW3207540205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.