Evidence map›Paper›PMID 34685005›Full record

ReviewNanomaterials (Basel, Switzerland)2021

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System.

Kalvatala Sudhakar, Shivkanya Fuloria, Vetriselvan Subramaniyan, Kathiresan V Sathasivam, Abul Kalam Azad, Shasank S Swain, Mahendran Sekar, Sundram Karupiah, Omji Porwal, Alaka Sahoo and 5 more

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kalvatala SudhakarSchool of Pharmaceutical Sciences (LIT-Pharmacy), Lovely Professional University, Jalandhar 144411, India.ORCID 0000-0002-1123-9864
Shivkanya FuloriaFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia.
Vetriselvan SubramaniyanFaculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.ORCID 0000-0002-9629-9494
Kathiresan V SathasivamCentre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Kedah, Malaysia.
Abul Kalam AzadAdvanced Drug Delivery Laboratory, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang Darul Makmur, Malaysia.ORCID 0000-0003-4874-1169
Shasank S SwainDivision of Microbiology and NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar 751023, India.
Mahendran SekarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh 30450, Perak, Malaysia.ORCID 0000-0002-3022-6137
Sundram KarupiahFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia.
Omji PorwalDepartment of Pharmacognosy, Tishk International University, Erbil 44001, KRG, Iraq.ORCID 0000-0003-1760-6618
Alaka SahooDepartment of Skin & VD, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar 751003, India.ORCID 0000-0002-6743-3885
Dhanalekshmi Unnikrishnan MeenakshiCollege of Pharmacy, National University of Science and Technology, Muscat 130, Oman.ORCID 0000-0002-2689-4079
Vipin Kumar SharmaDepartment of Pharmaceutical Sciences, Gurukul Kangri (Deemed to Be University), Haridwar 249404, Uttarakhand, India.
Sanjay JainFaculty of Pharmacy, Medicaps University, Indore 453331, MP, India.
R Narayana CharyuluDepartment of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Mangalore 575018, India.
Neeraj Kumar FuloriaFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A selected active pharmaceutical ingredient must be incorporated into a cargo carrier in a particular manner so that it achieves its goal. An amalgamation of active pharmaceutical ingredients (APIs) should be conducted in such a manner that it is simple, professional, and more beneficial. Lipids/polymers that are known to be used in nanocarriers for APIs can be transformed into a vesicular formulation, which offers elegant solutions to many problems. Phospholipids with other ingredients, such as ethanol and water, form suitable vesicular carriers for many drugs, overcoming many problems related to poor bioavailability, poor solubility, etc. Ultraflexible liposomes are novel carriers and new frontiers of drug delivery for transdermal systems. Auxiliary advances in vesicular carrier research have been made, enabling polymer-coated ethanolic liposomes to avoid detection by the body's immune system-specifically, the cells of the reticuloendothelial system. Ultraflexible liposomes act as a cargo system and a nanotherapeutic approach for the transport of therapeutic drugs and bioactive agents. Various applications of liposome derivatives in different diseases are emphasized in this review.

Indexed as

bioactiveethosomeliposometransethosomestransfersomes

Identifiers

PMID34685005
PMCPMC8537378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.