Evidence map›Paper›PMID 34684895›Full record

ArticleMolecules (Basel, Switzerland)2021

Deprotometalation-Iodolysis and Direct Iodination of 1-Arylated 7-Azaindoles: Reactivity Studies and Molecule Properties.

Mohamed Yacine Ameur Messaoud, Ghenia Bentabed-Ababsa, Ziad Fajloun, Monzer Hamze, Yury S Halauko, Oleg A Ivashkevich, Vadim E Matulis, Thierry Roisnel, Vincent Dorcet, Florence Mongin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Mohamed Yacine Ameur MessaoudInstitut des Sciences Chimiques de Rennes-UMR 6226, University of Rennes, CNRS, ISCR, 35000 Rennes, France.
Ghenia Bentabed-AbabsaLaboratoire de Synthèse Organique Appliquée, Faculté des Sciences Exactes et Appliquées, Université d'Oran 1 Ahmed Ben Bella, BP 1524 El M'Naouer, Oran 31000, Algeria.
Ziad FajlounLaboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, Lebanon.ORCID 0000-0002-6502-3110
Monzer HamzeLaboratoire Microbiologie, Santé et Environnement, Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University, Tripoli 1300, Lebanon.
Yury S HalaukoUNESCO Chair of Belarusian State University, 220030 Minsk, Belarus.
Oleg A IvashkevichResearch Institute for Physico-Chemical Problems, Belarusian State University, 220030 Minsk, Belarus.
Vadim E MatulisResearch Institute for Physico-Chemical Problems, Belarusian State University, 220030 Minsk, Belarus.
Thierry RoisnelInstitut des Sciences Chimiques de Rennes-UMR 6226, University of Rennes, CNRS, ISCR, 35000 Rennes, France.ORCID 0000-0002-6088-4472
Vincent DorcetInstitut des Sciences Chimiques de Rennes-UMR 6226, University of Rennes, CNRS, ISCR, 35000 Rennes, France.
Florence MonginInstitut des Sciences Chimiques de Rennes-UMR 6226, University of Rennes, CNRS, ISCR, 35000 Rennes, France.ORCID 0000-0003-3693-8861
Centre National de la Recherche Scientifique · FRBelarusian State University · BYLebanese University · LBUniversité Oran 1 Ahmed Ben Bella · DZ

Funding

Fonds Européen de Développement Régional 0French National Centre for Scientific Research 0Thermo Fischer 0University of Rennes 1 0
6 · The paper itself

Abstract

Five protocols were first compared for the copper-catalyzed C-N bond formation between 7-azaindole and aryl/heteroaryl iodides/bromides. The 1-arylated 7-azaindoles thus obtained were subjected to deprotometalation-iodolysis sequences using lithium 2,2,6,6-tetramethylpiperidide as the base and the corresponding zinc diamide as an in situ trap. The reactivity of the substrate was discussed in light of the calculated atomic charges and the p

Indexed as

7-azaindoledeprotometalationiodinationN-arylationregioselectivity

Identifiers

PMID34684895
PMCPMC8537530
OpenAlexW3205281367

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.