Evidence map›Paper›PMID 34684771›Full record

ArticleMolecules (Basel, Switzerland)2021

Standardized Extract of

Ken Shirato, Jun Takanari, Takako Kizaki

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Frontiers in nutrition · 2026
    Pooled it
  2. Article
  3. ETASPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Cytokines and microRNAs in SARS-CoV-2: What do we know?Molecular therapy. Nucleic acids · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ken ShiratoDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.ORCID 0000-0002-3151-9417
Jun TakanariAmino Up Co., Ltd., 363-32 Shin-ei, Kiyota, Sapporo 004-0839, Japan.
Takako KizakiDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
Kyorin University · JPAmino Up (Japan) · JP

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (C) (21K11472)Meiji Yasuda Life Foundation of Health and Welfare the 36th Research GrantNakatomi Foundation the 32nd Research Grant
6 · The paper itself

Abstract

Excessive host inflammation following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with severity and mortality in coronavirus disease 2019 (COVID-19). We recently reported that the SARS-CoV-2 spike protein S1 subunit (S1) induces pro-inflammatory responses by activating toll-like receptor 4 (TLR4) signaling in macrophages. A standardized extract of

Indexed as

AnimalsAsparagus PlantButadienesCell SurvivalInterleukin-1betaInterleukin-6MacrophagesMaleMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NitrilesPhosphorylationPlant ExtractsPlant StemsButadienesInterleukin-1betaInterleukin-6Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NitrilesPlant ExtractsProto-Oncogene Proteins c-aktSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Toll-Like Receptor 4U 0126Asparagus officinalis L.cell signalinginflammationmacrophageSARS-CoV-2spike protein

Identifiers

PMID34684771
PMCPMC8540605
OpenAlexW3205133392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.