Evidence map›Paper›PMID 34684770›Full record

ReviewMolecules (Basel, Switzerland)2021

The Spicy Story of Cannabimimetic Indoles.

Allyn C Howlett, Brian F Thomas, John W Huffman

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Effects of ΔCannabis and cannabinoid research · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Allyn C HowlettDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-2810-0164
Brian F ThomasDepartment of Analytical Sciences, The Cronos Group, Toronto, ON M5V 2H1, Canada.ORCID 0000-0002-0097-4804
John W HuffmanDepartment of Chemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0003-0289-2252
Clemson University · USWake Forest University · US

Funding

Cannabinoid Receptors and Associated Proteins-RenewalR01DA042157 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLYN C HOWLETT, W TODD LOWTHER · 2017 to 2026
$5.4M
THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
Behavioral Pharmacology of Synthetic CannabinoidsR03DA031988 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI WILEY, JENNY L. · 2011 to 2012
$197k
NIDA NIH HHS R01-DA003672NIDA NIH HHS R01-DA040460NIDA NIH HHS R01 DA042157NIDA NIH HHS R01-DA042157NIDA NIH HHS R03-DA031988
6 · The paper itself

Abstract

The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the ability of AAI analogs to block prostaglandin synthesis diminished, and antinociceptive activity was found to result from action at the CB

Indexed as

AnalgesicsAnimalsBenzoxazinesBinding SitesBiomimetic MaterialsCannabinoidsDesigner DrugsDrug DesignHumansIndolesLigandsMorpholinesNaphthalenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Static Electricity(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneAnalgesicsBenzoxazinesCannabinoidsDesigner DrugsIndolesLigandsMorpholinesNaphthalenespravadolineReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2allodyniaaminoalkylindoleantinociceptioncannabinoid receptorCP55940JWH-018K2pravadolinespiceWIN55212-2

Identifiers

PMID34684770
PMCPMC8538531
OpenAlexW3206399445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.