Evidence map›Paper›PMID 34684755›Full record

ArticleMolecules (Basel, Switzerland)2021

Marine Brominated Tyrosine Alkaloids as Promising Inhibitors of SARS-CoV-2.

Amr El-Demerdash, Afnan Hassan, Tarek Mohamed Abd El-Aziz, James D Stockand, Reem K Arafa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Amr El-DemerdashDepartment of Metabolic Biology & Biological Chemistry, The John Innes Center, Norwich Research Park, Norwich NR4 7UH, UK.ORCID 0000-0001-6459-2955
Afnan HassanDrug Design and Discovery Laboratory, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt.
Tarek Mohamed Abd El-AzizZoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.ORCID 0000-0002-3441-9673
James D StockandDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Reem K ArafaDrug Design and Discovery Laboratory, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt.ORCID 0000-0001-7527-1655
The University of Texas Health Science Center at San Antonio · USZewail City of Science and Technology · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been more than 150 million confirmed cases of SARS-CoV-2 since the beginning of the pandemic in 2019. By June 2021, the mortality from such infections approached 3.9 million people. Despite the availability of a number of vaccines which provide protection against this virus, the evolution of new viral variants, inconsistent availability of the vaccine around the world, and vaccine hesitancy, in some countries, makes it unreasonable to rely on mass vaccination alone to combat this pandemic. Consequently, much effort is directed to identifying potential antiviral treatments. Marine brominated tyrosine alkaloids are recognized to have antiviral potential. We test here the antiviral capacity of fourteen marine brominated tyrosine alkaloids against five different target proteins from SARS-CoV-2, including main protease (M

Indexed as

AlkaloidsAntiviral AgentsBinding SitesCoronavirus 3C ProteasesCOVID-19COVID-19 Drug TreatmentHalogenationHumansIsoxazolesMolecular Docking SimulationMolecular Dynamics SimulationSARS-CoV-2Spike Glycoprotein, CoronavirusStructure-Activity RelationshipTyrosine3C-like proteinase, SARS-CoV-2AlkaloidsAntiviral AgentsCoronavirus 3C Proteasesfistularin 3IsoxazolesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TyrosineADME/Toxbrominated tyrosine alkaloidsmolecular dockingmolecular dynamics simulationSARS-CoV-2virtual screening

Identifiers

PMID34684755
PMCPMC8537272
OpenAlexW3207853523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.