Evidence map›Paper›PMID 34684734›Full record

ArticleMolecules (Basel, Switzerland)2021

Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells.

Sithandiwe E Mazibuko-Mbeje, Sinenhlanhla X H Mthembu, Andani Tshiitamune, Ndivhuwo Muvhulawa, Fikile T Mthiyane, Khanyisani Ziqubu, Christo J F Muller, Phiwayinkosi V Dludla

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Hypoglycemic and hypolipidemic effects ofFood science & nutrition · 2024
    Article
  5. Bioactivity and mechanisms of flavonoids in decreasing insulin resistance.Journal of enzyme inhibition and medicinal chemistry · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sithandiwe E Mazibuko-MbejeDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.
Sinenhlanhla X H MthembuDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.ORCID 0000-0003-2747-1841
Andani TshiitamuneDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.ORCID 0000-0002-7992-4534
Ndivhuwo MuvhulawaDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.ORCID 0000-0003-2797-9717
Fikile T MthiyaneDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.
Khanyisani ZiqubuDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa.
Christo J F MullerBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.ORCID 0000-0001-6821-2120
Phiwayinkosi V DludlaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.ORCID 0000-0001-5965-3610
North-West University · ZASouth African Medical Research Council · ZA

Funding

National Research Foundation 113674National Research Foundation 128296
6 · The paper itself

Abstract

Our group has progressively reported on the impact of bioactive compounds found in rooibos (

Indexed as

AspalathusCell LineChalconesDiabetes Mellitus, Type 2FlavonoidsGene ExpressionGlucoseGlucosidesHepatocytesHumansInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceLiverPhosphatidylinositol 3-KinasesPlant ExtractsChalconesFlavonoidsGlucoseGlucosidesInsulinInsulin Receptor Substrate ProteinsorientinPhosphatidylinositol 3-KinasesPlant Extractsdyslipidemiaenergy metabolisminsulin resistanceorientinpalmitatetype 2 diabetes

Identifiers

PMID34684734
PMCPMC8538794
OpenAlexW3205555890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.