Evidence map›Paper›PMID 34684709›Full record

ArticleMolecules (Basel, Switzerland)2021

A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke.

Denis A Borozdenko, Aiarpi A Ezdoglian, Tatiana A Shmigol, Darya I Gonchar, Dmitri N Lyakhmun, Dmitri V Tarasenko, Yaroslav V Golubev, Elvira A Cherkashova, Daria D Namestnikova, Ilya L Gubskiy and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Drug Design for Cerebral Ischemia: A Molecular Perspective Review.CNS & neurological disorders drug targets · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Effect of a NewMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Denis A BorozdenkoDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Aiarpi A EzdoglianDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Tatiana A ShmigolDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0002-5195-0845
Darya I GoncharDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0003-3327-692X
Dmitri N LyakhmunDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Dmitri V TarasenkoDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Yaroslav V GolubevDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Elvira A CherkashovaDepartment of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine Federal State Budgetary Institution, Federal Center of Brain Research and Neurotechnologies, Federal Medical Bio-logical Agency, 117997 Moscow, Russia.
Daria D NamestnikovaDepartment of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine Federal State Budgetary Institution, Federal Center of Brain Research and Neurotechnologies, Federal Medical Bio-logical Agency, 117997 Moscow, Russia.ORCID 0000-0001-6635-511X
Ilya L GubskiyDepartment of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine Federal State Budgetary Institution, Federal Center of Brain Research and Neurotechnologies, Federal Medical Bio-logical Agency, 117997 Moscow, Russia.ORCID 0000-0003-1726-6801
Alexey A LaguninDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0003-1757-8004
Leonid V GubskyDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Vladimir P ChekhoninDepartment of Medical Nanobiotechnologies, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Sophia S BorisevichLaboratory of Physical Chemistry, Ufa Institute of Chemistry UFRS RAS, pr. Oktyabrya 71, 450054 Ufa, Russia.ORCID 0000-0001-8481-0470
Maxim A GureevLaboratory of Bioinformatics, Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov University, 119991 Moscow, Russia.ORCID 0000-0002-0385-922X
Anastasia D ShaginaDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Nina M KiselevaDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0003-1754-9051
Vadim V NegrebetskyDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Yuri I BaukovDepartment of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Pirogov Russian National Research Medical University · RUFederal Medical-Biological Agency · RUSechenov University · RUUfa Institute of Chemistry · RU

Funding

Russian Foundation for Basic Research 20-03-00858Russian Science Foundation 21-73-20250
6 · The paper itself

Abstract

We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound

Indexed as

AnimalsBehavior, AnimalBrain IschemiaCognitionDisease Models, AnimalGlutamic AcidInfarction, Middle Cerebral ArteryIschemic StrokeMaleMolecular Docking SimulationNeuronsNeuroprotective AgentsPrimary Cell CulturePyrrolidinesRatsRats, WistarGlutamic AcidNeuroprotective AgentspyrrolidinePyrrolidinesbehavioral testsexperimental ischemic strokeneuroprotective activitysynthesistransient MCAO

Identifiers

PMID34684709
PMCPMC8541353
OpenAlexW3206225974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.