Evidence map›Paper›PMID 34684684›Full record

ArticleMolecules (Basel, Switzerland)2021

Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice.

Yu-Young Lee, Ming Wang, Yurim Son, Eun-Ju Yang, Moon-Seok Kang, Hyun-Joo Kim, Hyung-Seok Kim, Jihoon Jo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Frontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yu-Young LeeDepartment of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
Ming WangDepartment of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea.
Yurim SonDepartment of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
Eun-Ju YangResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Daegu 41566, Korea.
Moon-Seok KangDepartment of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
Hyun-Joo KimDepartment of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
Hyung-Seok KimDepartment of Forensic Medicine, Chonnam National University Medical School, Gwangju 501-757, Korea.
Jihoon JoDepartment of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea.
Chonnam National University · KRRural Development Administration · KRKyungpook National University · KR

Funding

Cooperative Research Program for Agriculture Science & Technology Development PJ01255102
6 · The paper itself

Abstract

Memory deterioration in Alzheimer's disease (AD) is thought to be underpinned by aberrant amyloid β (Aβ) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a range of biological properties. Herein, we performed methanolic extraction of the Avns-rich fraction (Fr. 2) from germinated oats using column chromatography, and examined the effects of Avn-C on synaptic correlates of memory in a mouse model of AD. Avn-C was identified in Fr. 2 based on

Indexed as

Alzheimer DiseaseAnimalsAvenaDisease Models, AnimalGlycogen Synthase Kinase 3 betaHippocampusLong-Term PotentiationMaleMiceMice, TransgenicNeuronal Plasticityortho-AminobenzoatesPlant Extractsavenanthramide-2CGlycogen Synthase Kinase 3 betaGsk3b protein, mouseortho-AminobenzoatesPlant ExtractsAlzheimer’s diseaseamyloid βavenanthramide-Chippocampal synaptic plasticitymemoryoatspolyphenol

Identifiers

PMID34684684
PMCPMC8541156
OpenAlexW3205978628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.