Evidence map›Paper›PMID 34684683›Full record

ArticleMolecules (Basel, Switzerland)2021

Design, Microwave-Assisted Synthesis and In Silico Prediction Study of Novel Isoxazole Linked Pyranopyrimidinone Conjugates as New Targets for Searching Potential Anti-SARS-CoV-2 Agents.

Faisal K Algethami, Maher Cherif, Salma Jlizi, Naoufel Ben Hamadi, Anis Romdhane, Mohamed R Elamin, Mashael A Alghamdi, Hichem Ben Jannet

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Synthesis of bis-furyl-pyrrolo[3,4-RSC medicinal chemistry · 2023
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Faisal K AlgethamiDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia.ORCID 0000-0003-4280-1538
Maher CherifLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Medicinal Chemistry and Natural Products Team, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia.
Salma JliziLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Medicinal Chemistry and Natural Products Team, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia.
Naoufel Ben HamadiDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia.
Anis RomdhaneLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Medicinal Chemistry and Natural Products Team, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia.
Mohamed R ElaminDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia.
Mashael A AlghamdiDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia.
Hichem Ben JannetLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Medicinal Chemistry and Natural Products Team, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia.ORCID 0000-0001-5858-1803
University of Monastir · TNImam Mohammad ibn Saud Islamic University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel naphthopyrano[2,3-

Indexed as

Drug DesignAntiviral AgentsBinding SitesClick ChemistryCoronavirus 3C ProteasesCOVID-19COVID-19 Drug TreatmentHumansIsoxazolesMicrowavesMolecular Docking SimulationProtease InhibitorsPyrimidinonesSARS-CoV-2Structure-Activity RelationshipThermodynamics3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesIsoxazolesProtease InhibitorsPyrimidinonesclick chemistrycopper catalystin silicomolecular dockingisoxazolemicrowave irradiationpyranopyrimidinoneSARS-CoV-2 Mpro inhibitors

Identifiers

PMID34684683
PMCPMC8537412
OpenAlexW3206598600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.