Evidence map›Paper›PMID 34684667›Full record

ArticleNutrients2021

Immunoreactive Trypsinogen and Free Carnitine Changes on Newborn Screening after Birth in Patients Who Develop Type 1 Diabetes.

Jane Frances Grace Lustre Estrella, Veronica C Wiley, David Simmons

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jane Frances Grace Lustre EstrellaMacarthur Clinical School, Western Sydney University School of Medicine, Campbelltown 2560, Australia.
Veronica C WileyNSW Newborn Screening Program, Locked Bag 2012 Wentworthville, Sydney 2145, Australia.
David SimmonsMacarthur Clinical School, Western Sydney University School of Medicine, Campbelltown 2560, Australia.ORCID 0000-0003-0560-0761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Are free carnitine concentrations on newborn screening (NBS) 48-72 h after birth lower in patients who develop type 1 diabetes than in controls? A retrospective case-control study of patients with type 1 diabetes was conducted. NBS results of patients from a Sydney hospital were compared against matched controls from the same hospital (1:5). Multiple imputation was performed for estimating missing data (gestational age) using gender and birthweight. Conditional logistic regression was used to control for confounding and to generate parameter estimates (α = 0.05). The Hommel approach was used for post-hoc analyses. Results are reported as medians and interquartile ranges. A total of 159 patients were eligible (80 females). Antibodies were detectable in 86. Median age at diagnosis was 8 years. Free carnitine concentrations were lower in patients than controls (25.50 µmol/L;18.98-33.61 vs. 27.26; 21.22-34.86 respectively) (

Indexed as

Neonatal ScreeningAdolescentCarnitineChildChild, PreschoolCohort StudiesDiabetes Mellitus, Type 1FemaleHumansInfantInfant, NewbornMaleTrypsinogenCarnitineTrypsinogenacylcarnitinescarnitinedried blood spotsimmunoreactive trypsinogenmetabolic profilenewborn screeningtype 1 diabetes

Identifiers

PMID34684667
PMCPMC8538382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.